Maximum dose: 10 mg IM 2 to 4 hours apart; additional doses in patients with clinically significant postural hypotension are not recommendedComments:The efficacy of repeated doses in agitated patients has not been systematically evaluated in controlled clinical trials. The safety of total daily dose...
Also, the safety of total daily doses greater than 30 mg, or 10 mg injections given more frequently than 2 hours after the initial dose, and 4 hours after the second dose have not been evaluated in clinical trials. Maximal dosing of intramuscular olanzapine (e.g., 3 doses of 10 mg ...
Dosage10mgBritish Medical Association (2001)To be taken as a single dose. Adjust the dose if necessary within the range of 5–20 mg daily.Olanzapineis not recommended in children under 18 years. Contraindications Narrow angle glaucoma, lactation. Special precaution needs to be taken in patients ...
Carbamazepine (200 mg twice daily) increased clearance of olanzapine (single 10-mg dose) by about 50%; effect may be greater with higher carbamazepine dosages Consider increase in olanzapine dosage during concurrent use Charcoal Decreased peak plasma concentrations and AUC of oral olanzapine Cha...
510. Olanzapine and clozapine elevate prolactin levels after every daily doseanalgesiapainenkephalinmorphinemesencephalonhttp://linkinghub.elsevier.com/retrieve/pii/S0006322300007800doi:10.1016/S0006-3223(00)00780-0P. TurroneS. KapurM.V. Seeman
[drug overdose] In clinical trials, 67 patients had intentional or unintentional overdose, maximum dose of 300mg (normal daily dose of 5 ~ 20mg), symptoms only drowsiness and slurred speech, test results and ECG showed no abnormal vital signs are usually in the normal range. According to ...
At the end point, mean daily dosage of olanzapine was13.00±4.97mgintheomega-3and12.85±4.35mg in the placebo group (p=0.922). VPA mean dosage in omega-3 and placebo group were 749.00 ±189.73 and Discussion Inthisstudy,weevaluatedtheprobablebenefitsofdiet- ary doseofomega-3fatty acidson ...
As shown in healthy volunteers, maximum plasma olanzapine concentrations (Cmax) after single oral doses (2.5 to 12.2mg) are reached within about 5 hours. Values for Cmaxand area under the plasma concentration-time curve are proportional to the dose. The volume of distribution of olanzapine is ...
Olanzapine is well absorbed after oral administration in healthy volunteers and the absolute oral bioavailability (60 to 80%) is unaffected by food. Mean peak plasma concentrations (Cmax) of 11 μg/L after a single oral dose of 12.5mg are achieved in approximately 5 hours (tmax). Steady-stat...
Dosage unit compositions may contain such amounts of such submultiples thereof as may be used to make up the daily dose. It will be understood, however, that the specific dose level for any particular patient will depend upon a variety of factors: the type and degree of the cellular or ph...