Olanzapineis a second generationantipsychotic agentof the thienobenzodiazepine class. It is used inbipolar disorder, schizophrenia, and refractory depression.Olanzapineis a non-specific inhibitor of multiple 5HT, dopamine, andmuscarinic receptors. The binding for 5HT3 and dopamine-2 receptors account for...
To the best of our knowledge, this is the first meta-analysis to address the efficacy of OFC in acute bipolar depression not focused on a single drug class comparison. Similar questions were handled in a review evaluating placebo comparisons (only one study) (Vieta et al., 2010). The findi...
Subjects were free of active medical prob- lems or substance abuse during the six months preced- ing this study. Two patients participated in both the olanzapine treatment group and the drug-free compari- son group by virtue of having had a [I-123]IQNB SPECT scan during a drug-free ...
684 to Liversidge et. al., which is herein incorporated by reference, discloses particles of a drug substance having a non-crosslinked surface stabilizer absorbed on the surface thereof and methods for the preparation thereof. This patent does not teach or suggest nanoparticulate compositions of ...
However, there are substantial differences between drugs and there is no evidence for a “class” effect (De Fruyt et al., 2012). Thus while the effect ratio was 4.7 for quetiapine it was close to 3 for olanzapine and 0.19 for aripiprazole. Why specific antipsychotics such as qu...
The OLZ molecule has low solubility decreasing bioavailability, but has high permeability in membrane biological being classified as a Class II drug substance according to the Biopharmaceutics Classification System. It was reported many side effects of administering OLZ orally. So, in order to ...