和安慰剂比较,用奥氮平治疗的患者的死亡率有2倍的增加(分别为3.5%,1.5%)。但死亡发生率与奥氮平的剂量(平均日剂量为4.4mg)或治疗的周期无正相关性。导致死亡率升高的风险因素包括,年龄大于65岁,吞咽困难,镇静状态,营养不良和脱水,肺部疾病(如吸入或非吸入性肺炎),或同时服用苯二氮卓。然而,排除这些风险因素,...
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欧盟HMA上市药品数据库提供Olanzapine Ranbaxy 2,5 mg tablets药品的基本信息,包括通用名olanzapine,中文名奥氮平,ATC代码N05AH03 olanzapine以及上市许可持有人RANBAXY BELGIUM N.V. 1800 VILVOORDE, LEUVENSESTRAAT 28/2 BELGIUM等信息的查询.
A repeat challenge with olanzapine 2.5 mg/day led to a recurrence of oedema within 5 days; her oedema was successfully treated with furosemide again. Due to the unsucces ...doi:10.2165/00128415-200611170-00050Springer International PublishingReactions Weekly...
This trial compared the efficacy and safety of a single dose range of olanzapine, 5-20 mg/day, to a single dose range of haloperidol, 5-20 mg/day, in the treatment of 1996 in- and out-patients with a DSM-III-R diagnosis of schizophrenia, schizophreni-form disorder, or schizo...
This international, multicenter, double-blind, parallel trial compared the efficacy and safety of a single dose range of olanzapine, 5-20 mg/day, to a single dose range of haloperidol, 5-20 mg/day, in the treatment of 1,996 in- and out-patients with a DSM-III-R diagnosis of ...
Methods Solid tumors planned for anthracycline-cyclophosphamide & high-dose cisplatin chemotherapy was randomized (1:1) to receive either 10mg OLZ (standard arm) or 2.5mg (experimental arm) till day 4 with TAE regimen [5-hydroxytryptamine type 3 (5-HT3) receptor antagonists, dexamethasone (SD,...
with either olanzapine (1mg/kg), betahistine (2.7 mg/kg), olanzapine plus betahistine (O+B), or vehicle (control) for 2 weeks. Quantitative autoradiography was used to detect the density of [(3)H]ketanserin, [(3)H]paroxetine and [(3)H]raclopride binding site to 5-HT2AR, 5-HTT ...
To achieve a blood concentration of 20 ng/mL (the lower boundary of the recommended therapeutic range), simulation results indicated that the dose regimen of olanzapine should be 5 mg BID (twice a day), 鈮 5 mg QD (every day) plus 10 mg QN (every night), or >10 mg BID for ...
The t1/2 was 4.91 hours while k (reaction rate constant) was 0.1411h. These methods were based on extension region of the degradation product. All the proposed methods were validated and successfully applied for determination of OLZ in Olanza 5 mg tablets. The obtained results were ...