Although previously only available from food, isoflavones are now being marketed in health-food supplements or drinks, and tablets may soon be available over the counter as 'natural' hormone-replacement therapy. In cancer, anti-o... SA Bingham,C Atkinson,J Liggins,... - 《British Journal of...
Results of our present study also indicated the benefits of potential progesterone therapy for NSCLC patients. Lung cancer is one of the most common types of malignancies in the world and its frequency has consistently increased in both men and women over the years in many parts of the world ...
About 70% of breast cancers express oestrogen receptor α (ESR1/ERα) and are oestrogen-dependent for growth. In contrast with the highly proliferative nature of ERα-positive tumour cells, ERα-positive cells in normal breast tissue rarely proliferate.
operation and Development test guidelines No.455 (OECD TG455)34; however, oestrogen receptor antagonists frequently show opposing activities in different tissue types, and future studies would provide clues for this unknown mechanism. Moreover, we confirmed that halogen-containing bisphenol derivatives (...
Moreover, glomerular immune deposits were detected in <40% of the tamoxifen treated mice. The latter were mainly of the IgG2a but not of the IgG3 isotype. Conclusion: The results clearly show the remarkable therapeutic effects of tamoxifen on SLE of (NZB脳NZW)F1 female mice and suggest that...
Luciferase activity was measured in a Topcount luminescence counter (Canberra Packard, Schwadorf, Austria). Full agonist curves were constructed for oestradiol and the ER ligands using cells expressing either ERα or ERβ. Oestrogenic antagonist curves (10−11–10−6 M) for ERB-88 and ...
Moreover, ZEN analogs can induce estrogenic effects in human cells via genomic mechanisms [16] and can thus cause various diseases [17]. The effects of α-ZAL on the reproductive functions of ruminants were extensively studied during the 1970s and 1980s [12], [18], [19]. Injection with ...
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Moreover, mRNA profiles of Runx1-deficient mammary luminal epithelial cells from MMTV-Cre;Runx1f/f versus control mice (GSE 47377) indicated increased expression of Sox2 in response to Runx1 loss (Fig. 2f). Finally, as shown in Fig. 2g, SOX2 mRNA was markedly elevated in biopsies from ...
(p) one case of thyroid cancer. The remaining 16 cancer types were all IHC-negative, here exemplified by (n) colorectal cancer and (o) breast cancer. Brown: positive IHC staining; Blue: hematoxylin counter staining. BC: breast cancer. Scale bar indicates 50 μm. Arrows indicate examples ...