doctors prescribed hormone replacement therapy to relieve these symptoms, but for some people with female reproductive organs the risk of side effects outweigh the benefit. Fortunately, estrogen supplements are now available over the counter. These medications contain either lower dos...
Estrogen receptors are a group of proteins discovered inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two lessons of estrogen receptor exist: ER, which is a member of the nuclear hormone relatives of intracel
Enhanced marrow adipogenesis and bone resorption in estrogen-deprived rats treated with the PPARγ agonist BRL49653 (rosiglitazone). Calcif. Tissue Int. 75, 329–337 (2004). Article CAS PubMed Google Scholar Syed, F. A. et al. Effects of estrogen therapy on bone marrow adipocytes in ...
The use of unopposed estrogens in women who have a uterus is associated with an increased risk of endometrial cancer. 1. Cardiovascular disorders Estrogen and estrogen/progestin therapy has been associated with an increased risk of cardiovascular events such as myocardial infarction and stroke, as wel...
The cyclin D1-cyclin dependent kinases (CDK)4/6 inhibitor palbociclib in combination with endocrine therapy shows remarkable efficacy in the management of estrogen receptor (ER)-positive and HER2-negative advanced breast cancer (BC). Nevertheless, resistance to palbociclib frequently arises, highlighting...
In today’s modern indoor living, the most effective source of vitamin D3 (cholecalciferol) is an oil-based soft gel or liquid supplement. Vitamin D3 supplements are available over the counter in retail and online stores. Beware of vitamin D prescriptions as most contain vitamin D2 (ergocalci...
These results indicate that the exacerbation of postischemic leukocyte adhesion by chronic E2 replacement therapy in diabetic OVX females involves a RAGE-related mechanism. Targeting RAGE may restore the neuroprotective effect of E2 replacement therapy in diabetic females.Hao-Liang...
There is a strong association between obesity and colorectal cancer (CRC), especially in men, whereas estrogen protects against both the metabolic syndrome and CRC. Colon is the first organ to respond to high-fat diet (HFD), and estrogen receptor beta (E
Along this line, 41% of postmenopausal women become hypertensive, while more than 75% of women older than 60 years are hypertensive in the USA [10]. The majority of women older than 60 years has stage 2 HTN (BP ≥ 160/100 mmHg) or receives antihypertensive therapy [11,12,13]....
any side effects from the use of estrogen cream. It is often hard to determine if a side effect is caused by the cream or from something else. For example, if you experienced a headache while using the cream, it would be hard to say whether it was from the cream or from something ...