However, as anticipated with a short biological half-life secondary to rapid phase II metabolism and poor bioavailability [97], raloxifene is not superior to tamoxifen at equivalent doses [95]. Raloxifene maintains bone density in ovariectomised rats 29, 98, 99, 100, 101, 102, 103. In ...
Also the use of vaginal oestriol at conventional doses is associated with significant systemic absorption: it has 2680 R. Ponzone et al. / European Journal of Cancer 41 (2005) 2673–2681 been calculated that 1 mg of intravaginal estriol results in serum levels equivalent t...