The findings, published in the journal "The Lancet" this week, appear to support the use of low-dose oestrogen only therapies even in women with an intact uterus.Pedder, Catopulse
heart disease, but it is important to state that with the finding that hormone-replacement therapy (HRT) does not significantly reduce the risk for CHD [37] but, in fact, on balance is detrimental to women's health; there are opportunities in medicinal chemistry to develop new selective ...
induce more mitoses than oestrogen alone (the 'oestrogen plus progestagen hypothesis') or that oestrogen alone induces breast cell mitoses in a dose-dependent manner and that progesterone has no effect (the 'oestrogen alone hypothesis')... TJA Key,MC Pike - 《European Journal of Cancer & Clin...
Most agree that short-term oestrogen therapy, using the lowest effective dose, is a reasonable option for recently menopausal women with moderate-to-severe symptoms who are in good cardiovascular health (Martin and Manson. 2008. J. Clin. Endocrinol. Metab. 93, 4567-75). Whilst effective and ...
The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control study ObjectiveTo assess the thrombotic risk associated with oral contraceptive use with a focus on dose of oestrogen and type of progestogen of oral contracepti... ...
Endogenous sex hormones and C-reactive protein in healthy postmenopausal women Intrinsa is prescribed for women who are receiving oestrogen replacement therapy. It delivers a daily dose of testosterone from a patch replaced twice weekly and worn continuously on the lower abdomen. Trials criticised; In...
However, it is not clear whether the adverse effect of HRT is related to dosage and/or the presence of progestin. Using a mouse model of myocardial infarction (MI), we studied the dose-effect of oestrogen replacement on mortality and cardiac remodelling and dysfunction post-MI in the absence...
HRT should be used in the lowest possible dose for the shortest possible time. Women harbouring asymptomatic gallstones should not receive oestrogens because of the possibility of developing cholecystitis.doi:10.1517/14740338.5.1.117Dhiman, Radha K...
HRT should be used in the lowest possible dose for the shortest possible time. Women harbouring asymptomatic gallstones should not receive oestrogens because of the possibility of developing cholecystitis.RadhaPostgraduateKPostgraduateDhimanPostgraduate...
These concerns arose mainly from the use of high-dose synthetic oestrogen preparations used in the past for local relief of urogenital atrophy. The newer estriol and estradiol-containing vaginal hormone therapies are safe for short-term use. However, the majority of these preparations are only ...