1.OECD Guideline for Testing of Chemicals:In VitroMammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene. TG 490. Adopted 29 July 2016. 2.OECD Guideline for Testing of Chemicals:In VitroMammalian Cell Gene Mutation Test. TG 476. Adopted 21st July 1997. ...
C hinese Journal of NewDrugs 2015,24(18) · · 新药申报与审评技术 OECD 遗传毒性最新修订指导原则的解析 1 1 1 2 2 1 周 , , , , , 王征涂 黄 王 常艳 长慧 宏刚 芳华 庆利 (1 , 201203 ;2 , 100038) 国家上海新药安全评价研究中心 上海 国家食品药品监督管理局药品审评中心 北京 [ ] 、...
当前被OECD正式批准并现行的化学品遗传毒性评价指导原则TGs 主要有细菌回复突变试验( TG471)[5]、体外哺乳动物染色体畸变试验(TG473)[6]、哺乳动物红细胞微核试验(TG474)[7]、哺乳动物骨髓染色体畸变试验(TG475)[8]、体外哺乳动物细胞基因突变试验((TG476)[9]、体内哺乳动物肝细胞程序外DNA合成试验((TG486)[10...
TG 490 is written for the MLA and, because it also utilizes the TK locus, the TK6. While the MLA has been widely used for regulatory purposes, the TK6 has been used much less frequently. It should be noted that in spite of the similarity between the endpoints the two cell lines are...
当前被OECD正式批准并现行的化学品遗传毒性评价指导原则TGs 主要有细菌回复突变试验( TG471)[5]、体外哺乳动物染色体畸变试验(TG473)[6]、哺乳动物红细胞微核试验(TG474)[7]、哺乳动物骨髓染色体畸变试验(TG475)[8]、体外哺乳动物细胞基因突变试验((TG476)[9]、体内哺乳动物肝细胞程序外DNA合成试验((TG486)[10...