TG 471. Adopted July 1997. OECD Principles of Good Laboratory Practice (as revised in 1997). OECD Environmental Health and Safety Publications. OECD. 1. 1998. Explore Other Options In Vitro Comet Assay In Vitro Mammalian Cell Gene Mutation Test (OECD 490) In Vitro Mammalian Cell ...
At the 2017 IWGT meeting in Tokyo, one working group addressed the sensitivity and selectivity of the bacterial strains specified in the Organization for Economic Cooperation and Development (OECD) Test Guideline TG471 to recommend possible modification of the test guideline. Three questions were ...
TG 487. Adopted 26 September 2014. 2. OECD Principles of Good Laboratory Practice (as revised in 1997). OECD Environmental Health and Safety Publications. OECD. 1. 1998. Explore Other Options In Vitro Comet Assay In Vitro Mammalian Cell Gene Mutation Test (OECD 490) In Vitro Mammalian ...
(2007),人用药物注册技术要求国际协调会议(ICH)于2011年颁布的S2(R1)和世界经济合作与发展组织(OECD)陆续颁布的TGs.当前被OECD正式批准并现行的化学品遗传毒性评价指导原则主要有细菌回复突变试验(TG 471),体外哺乳动物染色体畸变试验(TG 473),哺乳动物红细胞微核试验(TG 474),哺乳动物骨髓染色体畸变试验(TG 475),...
Of the mutagens detected by the full TG471 strain battery, 93% were detected using only strains TA98 and TA100; consideration of results from in vitro genotoxicity assays that detect clastogenicity increased this to 99%. 展开 关键词: Bacterial mutagenicity Salmonella Ames assay E. coli WP2 ...
41、esupdatesmost recently updated471bacterial reverse mutation test26 may 1983121 july 1997472genetic toxicology: escherichia coli, reverse assay26 may 19830date of deletion:21 july 1997(method merged with tg471)473in vitro mammalian chromosome aberration test26 may 1983221 july 199726september 2014474 ...
1. 规范性:急性经皮毒性试验是根据国家、国际相关标准和指南进行的,包括OECD TG 404、GB/T 26340等。试验方法和操作步骤都有一定的规范性,以确保试验的可重复性和可比性。 2. 使用动物模型:急性经皮毒性试验通常利用实验动物(如小鼠、大鼠等)作为试验模型。动物皮肤和人类皮肤在结构和功能上的相似性相对较高,可...
C hinese Journal of NewDrugs 2015,24(18) · · 新药申报与审评技术 OECD 遗传毒性最新修订指导原则的解析 1 1 1 2 2 1 周 , , , , , 王征涂 黄 王 常艳 长慧 宏刚 芳华 庆利 (1 , 201203 ;2 , 100038) 国家上海新药安全评价研究中心 上海 国家食品药品监督管理局药品审评中心 北京 [ ] 、...
In a reverse gene mutation assay [OECD TG 471], MMB was not mutagenic in Salmonella typhimurium TA100, TA1535, TA98, TA1537, and TA 1538 or in Escherichia coli WP2 uvrA either with or without an exogenous metabolic activation. In a chromosomal aberration test [OECD TG 473], MMB did ...
(MMB)at2000mg/kgbw,therewasnodeath,clinicalsignorabnormalityatnecropsyinSDrats.TheacutedermalLD50wasconsideredtobemorethan2000mg/kgbw.Inanacuteoraltoxicitystudy[OECDTG401],Crj:CDSDrats(5animals/sex/dose)weregivenMMBbygavageat0,2000,3200,4000or5000mg/kgbwformalesandfemales.Deathswerefoundinmalesand...