例如,在双侧输尿管梗阻的大鼠中发现Oat1表达增加[19],而肾切除术引起的慢性肾衰竭可以降低OAT1表达[20]。OAT3表达被HNF1α/β反式激活,而OAT3启动子活性被DNA甲基化抑制[21]。 临床意义 由于药物暴露,OAT1和3涉及DDI和肾脏毒理学。肾脏OAT主要消除的药物包括抗病毒的药(例如oseltamivir)和奥美沙坦[22,23]。...
阴离子转运蛋白OAT1和OAT3与药物代谢相互影响的研究进展.pdf,ChinJ ClinPharmacoI 957 V01.26No.12December 2010(SenalNo.134) 蘑谣汹0矗越豳■盔缁圈 阴离子转运蛋白OATl和OAT3与药物代谢相互 影响的研究进展 intheinteractionbetweenthe anion Progress organ transpor
阴离子转运蛋白(OAT)OAT1与OAT3同属SLC22A家 族,主要在近端肾小管上皮细胞基底侧膜表达,在肝脏,肠和大脑亦有分布.它们介导有机阴离子进入其分布的细胞,进而参与多种药物在肾脏的分泌,重吸收和在 体内的分布等.本文从OAT1和OAT3的分子生物学基础,主要功能,介导药物相互作用的机制和毒性的产生,研究其使用的模...
目的初步检测缩泉丸和真武汤对小鼠肾脏有机阴离子转运体(Oats)中的2个主要亚型(Oat1,Oat3)的影响.方法以缩泉丸和真武汤及方中各药水煎剂,丙磺舒,氢氯噻嗪给NIH小鼠灌胃,每天2次,连续5 d,另设纯水对照组.末次给药后所有受试鼠逐一经尾静脉注入对氨基马尿酸(para-aminohippuric acid,PAH)30mg·kg-1,然后在1...
OAT1 and OAT3, which show the broad substrate specificities, are the major OATs in the kidney (Maeda et al., 2014). Most β-lactam antibiotics have been shown to interact with OAT1 and OAT3. For instance, piperacillin could inhibit the uptake of p-aminohippurate (PAH) in OAT1 cRNA-...
The inhibitory function of Radix lsatidis probably stems from indigo and indirubin contained in it.%目的:探讨板蓝根颗粒剂( GRl)和饮片水煎剂( DRl)及其所含主要成分靛蓝和靛玉红对小鼠肾有机阴离子转运体( OAT)中3个主要亚型Oat1,Oat2和Oat3的影响。方法 NlH小鼠分别ig给予GRl 0.615...
The expression of both OAT1 and OAT3 along the isolated rabbit renal proximal tubule (RPT) was determined using RT-PCR. They were found to be very strong in S2 segment and weak in S1 and S3 segments. We further examined the relative transport activity of these transporters in isolated ...
Km and Vmax values of entecavir were 250μM and 0.83nmol/mg protein/30s (OAT1) and 23μM and 1.1nmol/mg protein/30s (OAT3), respectively. Entecavir is the substrate of OAT1, OAT3, and OCT. Moreover, OAT1 and OAT3 are the targets of DDI between entecavir and JBP485. 展开 ...
OAT1 and OAT3 of the the organ anion transport protein(OAT)belong to amphiphilic solute transporter family 22A(SLC22A),a subset of the major facilitator superfamily.Several immunohistochemical studies have demonstrated that OAT1 and OAT3 are localized to the basolateral membrane of the proximal tubul...
ai\'ve learned a lot that way i \ ‘学会的ve很多那方式[translate] aIn vitro, ticagrelor and its major metabolites (AR-C124910 and AR-C133913) were found to inhibit various organic anion transporters that are involved in urate secretion (OAT1 and OAT3) 正在翻译,请等待...[translate]...