“基于寡糖代谢工程的正常和肿瘤细胞中Mucin型O-糖链的质谱定性定量比较分析”出自《高等学校化学学报》期刊2018年第9期文献,主题关键词涉及有Mucin型O-糖链、肿瘤细胞、正常细胞、寡糖代谢工程、质谱等。钛学术提供该文献下载服务。
摘要: Mucin O-glycans are conjugated carbohydrate chains that contain at the reducing terminus N-acetylgalactosamine linked covalently to serine/threonine in the peptide backbone. They are found in mucins a关键词: Animals Humans Mesocricetus Colorectal Neoplasms N-Acetylglucosaminyltransferases 1,4-alpha...
Mucin-type O-glycans have multiple functions. They bind bacteria and viruses, they function as receptors for carbohydrate binding proteins and are important components of the immune response. Glycosyltransferase expression and activity have been found to be abnormal in disease conditions. The structural ...
The mucinO-glycan structures are commonly terminated by sulfate, fucose, and sialic acid residues. The terminal display of sialic acid and sulfate sequester pathogens act as binding targets and modulate adhesion. It has been reported that sialic acid residues on mucin can offer a favorable environme...
Chemical NameMucin CAS No.7558-19-2 Molecular FormulaC6H10O8 Molecular Weight210.138 PubChemID607 EINECS208-404-0 Synonyms2,3,4,5-tetrahydroxyhexane-1,6-dioic acid; 2,3,4,5-Tetrahydroxy-hexanedioic acid; galactaric acid; View More7558...
Mucin-type GalNAc O-glycosylation is one of the most abundant and unique post-translational modifications. The combination of proteome-wide mapping of GalNAc O-glycosylation sites and genetic studies with knockout animals and genome-wide analyses in humans have been instrumental in our understanding of...
mucin proteins serve as a continuous endogenous source of MACs for resident microbes; here we investigate the potential role of purified, orally administered mucus glycans in maintaining a healthy microbial community. In this study, we liberated and purifiedO-linked glycans from porcine gastric mucin ...
Here, overviews of the present knowledge of invertebrate mucin-type O-glycan structures and the currently identified enzymes responsible for the biosynthesis of these oligosaccharides are presented, and the few data dealing with functional aspects of O-glycans are summarised. 展开 ...
Engineering of Sialylated Mucin-type O-Glycosylation in Plants Proper N- and O-glycosylation of recombinant proteins is important for their biological function. Although the N-glycan processing pathway of different exp... Castilho,Neumann,Daskalova,... - 《Journal of Biological Chemistry》 被引量:...
gingivalis Arg-gingipain B (RgpB) is able to cleave the MUC2 mucin at a specific site that will cause the mucus polymer to dissolve. Furthermore, we show that this cleavage site can be selectively blocked by site-specific O-glycosylation of the Thr located adjacent to the cleavage site by...