Comparison of sequences surrounding the modified serine on these and other proteins led to the proposal of a consensus sequence for O -glucosylation, C1-X- S -X-P-C2, where C1 and C2 are the first and second conserved cysteines of the EGF repeat (Harris and Spellman 1993). Database ...
Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Protein O-glucosylation is a conserved post-translational modification that occurs on epidermal growth factor-like (EGF) repeats harboring the C1-X-S-X-P-C2 consensus sequence. The Drosophila pr...
O-Glucosyltransferase1 (POGLUT1) is a homologue of Rumi from Drosophila, an endoplasmic reticulum (ER)-retaining glucosyltransferase, that adds glucose to serine residues within the consensus sequence of C1‑X‑S‑X‑P‑C2 in Notch EGF repeats, thereby regulating cell-fate decisions (1)...
AO-glucosyltransferases have a signal peptide (SP) at the beginning of sequence, a CAP10 domain, and a ER-retention signal. Both KTEL and REEL retention signals have a lower affinity for ERD receptors than the KDEL signal. POGLUT1 shares 52% identity with Rumi and is the only enzyme th...
Protein O-glucosyltransferase 1/Rumi-mediated glucosylation of Notch epidermal growth factor-like (EGF-like) domains plays an important role in Notch signaling. Protein O-glucosyltransferase 1 shows specificity for folded EGF-like domain... Z Li,M Fischer,M Satkunarajah,... - 《Nature Communicatio...
Jafar-Nejad, Regulation of mammalian Notch signaling and embryonic de- velopment by the protein O-glucosyltransferase Rumi, Development 138 (2011) 1925-1934.R. Fernandez-Valdivia, et al., Regulation of mammalian Notch signaling and em- bryonic development by the protein O-glucosyltransferase Rumi, ...
Protein O-Glucosyltransferases Rumi (RUMI)doi:10.1007/978-4-431-54240-7_131These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.Takeuchi, Hideyuki...