An assay to detect ghrelin O-acyltransferase activity using an acrylodan-labeled peptide mimic of ghrelin that provides for high-throughput screening for ghrelin O-acyltransferase inhibitors and detection via high performance liquid chromatography. Alternatively, the assay for ghrelin acylation may be ...
Nucleic acid compositions encoding polypeptide products with diglyceride acyltransferase activity, as well as the polypeptide products encoded thereby and methods for producing the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including ...
Molecular Function: glycerone-phosphate O-acyltransferase activity; palmitoyl-CoA hydrolase activity; receptor bindingBiological Process: response to drug; response to starvation; synaptogenesis; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; cerebellum...
Investigations have been carried out on the influence of membrane lipid composition and physical state on acyl-CoA: 1-acyl-glycerol-3-phosphoethanolamine O-acyltransferase activity in rat liver plasma membranes. The lipid composition of the membranes was modified either by way of lipid transfer protein...
Nucleic acid compositions encoding mammalian DGAT2α polypeptide products with diglyceride acyltransferase activity, as well as the mammalian DGAT2α polypeptide products encoded thereby and methods for producing the same, are provided. The subject DGAT2α polypeptide and nucleic acid compositions find use...
The activity of 1-acylglycerophosphocholine (1-acyl-GPC) O-acyltransferase (EC 2.3.23) varied during maturation of safflower (Carthamus tinctorius L.) seeds, and activity per seed was highest in the middle period of seed development when triacylglycerol (TAG) is most rapidly synthesized. The spe...
申请号：AU4712499 申请日：19990623 公开号：AU4712499A 公开日：20000110 专利内容由知识产权出版社提供 摘要：Nucleic acid compositions encoding polypeptide products with diglyceride acyltransferase activity, as well as the polypeptide products encoded thereby and methods for producing the same, are provided. ...
FIGURE 2. The IWP compounds specifically inhibit Porcn acyltransferase activity. A, IWP2 inhibits Wnt fatty acylation. Cells transfected with an expression construct expressing either a fusion molecule consisting of Wnt3A and the Fc region of human IgG (Wnt3A-Fc) or IgG-Fc (Fc) alone are trea...
A more detailed characterization of its anti-chlamydial activity showed FR179254 at 20 渭M to dramatically inhibit growth of the rapidly growing C. trachomatis serovar L2, resulting smaller and less...
Tanaka, A. et al., " Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT). Part I: Identification and structure-activity relationships of a novel series of substituted N-alkyl-N-biphenylylmethyl-N'-arylureas, " Bioorg. Med. Chem. (1998) 6:15-30....