通过在体外修饰这些肽以产生O-GlcNAcylated或未修饰的肽。使用表面等离子体共振(SPR)分析,确认了O-GlcNAcylated肽和importin α3之间的直接相互作用,但未修饰的肽与importin α3之间没有直接的相互作用(图4G)。这些结果表明O-GlcNAc修饰可以显著增强SRPK2与importin α蛋白的相互作用,表明importin α可能是O-GlcNAc修...
O型GlcNAcylated 。 匿名 2013-05-23 12:23:18 O-GlcNAcylated。 匿名 2013-05-23 12:24:58 O-GlcNAcylated。 匿名 2013-05-23 12:26:38 O-GlcNAcylated。 匿名 2013-05-23 12:28:18 O-GlcNAcylated.热门同步练习册答案初中同步测控优化设计答案 长江作业本同步练习册答案 名校课堂助教...
O -GlcNAcylated peptides and proteins for structural and functional studies 来自 Semantic Scholar 喜欢 0 阅读量: 98 作者:AT Balana,SP Moon,MR Pratt 摘要: O-GlcNAcylation is an enzymatic post-translational modification occurring in hundreds of protein substrates. This modification occurs through the...
(anon-O-GlcNAcylatedformofc-Jun)withPuGNActreatmentdidnotexertasimilareffect.GSHdownregulationinducedbyerastinwasrestoredbyoverexpressionofc-Jun-WTwithsi-multaneousPuGNActreatment.Inaddition,overexpressionofc-Jun-WT,butnotitsS73Amutant,inducedPSAT1andCBStranscriptionviadirectlybindingtotheirpromoterregions,...
Hepatic Manipulation of OGT Perturbs the DiurnalRhythm of Glucose HomeostasisIn line with the results from U2OS cells (Figure 1C), immunopre-cipitation analysis of O-GlcNAcylated proteins from mouse liversshows diurnal variations in O-GlcNAcylation of BMAL1 andCLOCKthatpeakinthefed/darkphase(...
This O-GlcNAcylated protein-like substance contains at least one unit selected from the group consisting of an N-acetylglucosamine unit, carboxy group-containing radical polymerizable units, a styrene unit, a polyethyleneimine unit, a poly-L-lysine unit, and a biotin unit. This fibrosis therapeutic...
O-GlcNAcylated proteins were galactosylated and separated by lectin affinity chromatography; >20% of the translated GLUT4 appeared to be O-GlcNAcylated. ... MG Buse,KA Robinson,BA Marshall,... - 《Am J Physiol Endocrinol Metab》 被引量: 236发表: 2002年 dbOGAP - An Integrated Bioinformatic...
We found O-GlcNAcylated site in ncOGT outside of TPR by using Q-TOF MS. Now we focus on the activities and function of ncOGT by mutagenesis studies. This ongoing effort would give us clear understanding of the key enzyme of O-GlcNAc metabolism and how the O-GlcNAc modification may be...
Levels of O-GlcNAcylated proteins, HSP90 and O-GlcNAc transferase (OGT, the enzyme responsible for O-GlcNAcylation) in COCs were measured using western... Frank L.A.,Sutton-McDowall M.L.,Brown H.M.,... - 《Human Reproduction》 被引量: 28发表: 2014年 Post-translational O-GlcNAcylatio...
linked GlcNAc (O-GlcNAc) modification is regulated by a pair of evolutionary conserved enzymes: O-GlcNAc transferase (OGT) catalyzes the attachment of the GlcNAc moiety from UDP-GlcNAc to target proteins [7,8], whereas O-GlcNAcase (OGA) removes O-GlcNAc from O-GlcNAcylated proteins [9,10]...