3 Alpen B, Gure AO, Scanlan MJ , et al .A new member of the NY-ESO-1 gene family is ubiquitously expressed in somatic t issues and evolutionarily conserved[ J] .Gene, 2002, 297(1-2):141-149. 4 Stockert E, Jager E, Chen YT, et al .A survey of the humoral immune re- sponse...
官方名 CTAG1A 官方全稱 cancer/testis antigen 1A HGNC ID HGNC:24198 別稱 ESO1, LAGE2A 位點類型 gene with protein product 染色體位置 Xq28 HCOP Orthology Predictions for CTAG1AFrom HGNC NY-ESO-1 試劑 All NY-ESO-1 Reagents NY-ESO-1 cDNA Clones ...
Cancer testis antigen gene 1B (CTAG1B) and its associated gene product; New York oesophageal squamous carcinoma 1 (NY-ESO-1), represent a unique and promising target for cancer immunotherapy. As a member of the cancer testis antigen family (CTA), the protein's restricted expression pattern ...
Background: NY-ESO-1 is a highly immunogenic cancer-testis antigens and it is a potential candidate for immunotherapy. Cellular expression of NY-ESO-1 gene is het- erogeneous depending on the demethylation status of its promoter. Exposure to 5-aza-2'-deoxycytidine (5-aza-CdR) has been ...
[0175] CAR的结合结构域后面可能有一个“间隔区”或“铰链”,它是指将抗原结合结构域 从效应细胞表面移开以实现适当的细胞/细胞接触、抗原‑结合和激活的区域(Patel等人, 《基因治疗(Gene Therapy)》,1999;6:412‑419)。CAR中的铰链区通常位于跨膜(TM)和结合 结构域之间。在某些实施例中,铰链区是免疫球...
NY-ESO-1 is a tumor-specific antigen of the cancer/testis antigen family and is encoded by a gene located at Xq28. It is composed of 180 amino acids with a molecular weight of 18 kD. NY-ESO-1 is strongly expressed in various types of cancers, but not in normal somatic tissues or ce...
Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease. Nat. Med. 16, 198–204 (2010). Article CAS PubMed Google Scholar Levine, B.L. et al. Effects of CD28 costimulation on long-term proliferation of CD4+ T...
andlocalizationofCrAG.ageneencodinganautoim- munogeniccancer-testisantigenES()-1.tohuman chromosomeXq28.CytogenetCeUGenet,1997,79(3 — 4):237-240 [43Sehultz-ThaterE,NoppenC,GudatF,eta1.NY-ES()- 1tumourassociatedantigenisacytoplasmicproteinde- ...
本发明属于医药领域,具体涉及一种能够特异性识别ny-eso-1(157-165)表位(sllmwitqc,hla-a*0201)的t细胞受体(tcr)或其抗原结合片段。 背景技术: 2011年,癌症超过心脏病,成为全球第一大死亡原因。who在2013年12月公布,全球每年新增癌症患者数已经超过1400万名,这与2008年的统计结果1270万人相比,人数大幅增加。同期...
Gene Symbol NY-ESO-1 Gene ID (NCBI) 246100 RRID AB_10638144 Conjugate Unconjugated Form Liquid Purification Method Antigen affinity purification UNIPROT ID P78358 Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Storage Conditions Store at -20°C. Stable for one year after...