Jewell JL, Guan KL. 2013. Nutrient signaling to mTOR and cell growth. Trends in Biochemical Sciences 38:233-242. doi: 10.1016/j.tibs.2013.01.004.Jewell JL , Guan KL ( 2013 ) Nutrient signaling to mTOR and cell growth . Trends Biochem Sci 38 : 233 – 242...
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. mTOR/RAFT1/FRAP is the target of the immunosuppressive drug rapamycin and the central component of a nutrient- and hormone-sensitive signaling pathway that... DH Kim,DD Sarbassov,SM Ali,...
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Nutrient signaling to mTOR and cell growth The mammalian target of rapamycin (mTOR) is a conserved protein kinase involved in a multitude of cellular processes including cell growth. Increased mTOR ... JL Jewell,KL Guan - 《Trends in Biochemical Sciences》 被引量: 377发表: 2013年 Nutrient regu...
et al. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 10, 457–468 (2002). Article CAS PubMed Google Scholar Liu, G. Y. & Sabatini, D. M. mTOR at the nexus of nutrition, growth, ageing and disease. Nat. Rev....
The mammalian target of rapamycin (mTOR), in response to the energy state, nutrient status, and growth factor stimulation of cells, plays a pivotal role in the coordination of cell growth and the cell cycle. Here, we review how the nutrient-sensing mTOR-signaling cascade molecularly integrates ...
Dual PI-3 kinase/mTOR inhibition impairs autophagy flux and induces cell death independent of apoptosis and necroptosis The PI-3 kinase (PI-3K)/mTOR pathway is critical for cell growth and proliferation. Strategies of antagonising this signaling have proven to be detrimental... RW Button,JH Vinc...
mTOR/RAFT1/FRAP is the target of the immunosuppressive drug rapamycin and the central component of a nutrient- and hormone-sensitive signaling pathway that regulates cell growth. We report that mTOR forms a stoichiometric complex with raptor, an evolutionarily conserved protein with at least two role...
protein kinase that regulates cell growth and metabolism, as well as cytokine and growth-factor expression, in response to environmental cues. mTOR receives stimulatory signals from RAS and phosphoinositide 3-kinase downstream of growth factors and nutrients, such as amino acids, glucose and oxygen. ...
mTOR is activated in response to hormones and growth factors, such as insulin and insulin-like growth factor 1 (IGF-1), and via the phosphatidylinositol 3-kinase-Akt signaling pathway in the presence of amino acids. Amino acids also induce mTOR activity in the absence of additional stimuli. ...