Raptor结合于mTOR的heat repeats结构域。Raptor可以结合于底物的TOS(TOR signaling)结构域,从而促进mTORC1的底物募集,而且其是mTORC1的正确亚细胞定位所必需的。 mLST8与mTORC1的激酶结构域(是环形结构)结合,可能起到稳定mTOR激酶激活环的作用。而FKBP12-rapa(FKBP12蛋白与雷帕霉素形成的复合物)可以结合于mOTR的FRB结...
[1]http://www.360doc.com/content/18/1227/19/52645714_804891330.shtml [2]Saxton, Robert A., and David M. Sabatini. "mTOR signaling in growth, metabolism, and disease." Cell 168.6 (2017): 960-976. [3]Fu, Wenxiang, and Michael N. Hall. "Regulation of mTORC2 Signaling." Genes 11.9 ...
其中北大-清华生命科学联合中心的刘颖教授团队“KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing”就是其中一文,因此下文我们将对mTOR信号通路进行比较详细的解读。同时,以下内容以2017年度《Cell》四大最佳综述之一的“mTOR Signaling in Growth, Metabolism, and Disease”为...
1. Saxton, R.A. and D.M. Sabatini, mTOR Signaling in Growth, Metabolism, and Disease. Cell, 2017. 169(2): p. 361-371.2. Wolfson, R.L. and D.M. Sabatini, The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway. Cell Metab, 2017. 26(2): p. 301-309.3. Liu,...
(B) The varying effects of rapalogs, catalytic mTOR inhibitors, or a combination of an mTOR inhibitor and autophagy inhibitor on cancer proliferation and survival. (C) The role of mTORC1 signaling in aging.在卡路里限制或者Rapamycin的条件下可以延缓衰老的过程(负负得正)...
Saxton RA, Sabatini DM. mTOR Signaling in Growth, Metabolism, and Disease. Cell. 2017 Mar 9;168(6):960-976. Murugan AK. mTOR: Role in cancer, metastasis and drug resistance. Semin Cancer Biol. 2019;59:92-111. Grabiner BC, Nardi V, Birsoy K, Possemato...
1. Saxton, R.A. and D.M. Sabatini, mTOR Signaling in Growth, Metabolism, and Disease.Cell, 2017. 169(2): p. 361-371. 2. Dibble, C.C. and B.D. Manning, Signal integration by mTORC1 coordinates nutrient in...
[1] R.A. Saxton, D.M.J.C. Sabatini, mTOR Signaling in Growth, Metabolism, and Disease, 168(6) (2017) 960-976. [2] D. Mossmann, S. Park, M.N.J.N.R.C. Hall, mTOR signalling and cellular metabolism are mutual determinants in cancer. ...
1. mTOR signalling and cellular metabolism are mutual determinants in cancer. Nature Review. doi.org/10.1038/ s41568-018-0074-8 2. Robert A. Saxton, David M. Sabatini. (2017). mTOR Signaling in Growth, Metabolism, and Disease. Cell 168, 960-976 ...
参考文献：Saxton RA, Sabatini DM. mTOR Signaling in Growth, Metabolism, and Disease. Cell. 2017 ...