Comparison of nucleoside and nucleotide analogs in the recurrence of hepatitis B virus-related hepatocellular carcinoma after surgical resection: A multicenter studyhepatitis B virushepatocellular carcinomanucleos(t)ide analogsrecurrenceresectionBackground Antiviral therapy should reduce the recurrence of ...
ChemInform Abstract: Acyclic Nucleoside and Nucleotide Analogs: A New Class of Antiviralsorganic chemistry, reviewnucleic acidsChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an ...
A systematic review was conducted to evaluate whether or not antiviral therapy with nucleotide/nucleoside analogs (NA) have survival benefit for patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after curative treatment. An electronic search of PubMed, EMBASE, and the Cochr...
Cyclization of nucleoside 5′-trichloromethyl phosphonates. Chem Pharm Bull (Tokyo) 23:2295–2300 CAS Google Scholar Marumoto R, Yoshioka Y, Naka T, Shima S, Miyashita O, Maki Y, Suzuki T, Honjo M (1979) Synthesis and enzymatic activity of adenosine 3′,5′-cyclic phosphate analogs. ...
Two families of nucleoside analogs have been developed to treat viral infections and cancer, but these compounds can cause tissue- and cell-specific toxicity related to their uptake and subcellular activity, which are dictated by host enzymes and transporters. Cellular uptake of these compounds require...
1.3. Nucleoside analogs as therapeutic agents The increased awareness that started in the 1960s of the therapeutic significance of modified nucleosides in the treatment of viral and bacterial infections quickly led to the syntheses of small molecules that do not destroy viral pathogens but rather inhib...
Moreover, such findings may be extended for evaluat- ing or improving therapeutic efficacy for other viral infections such as hepatitis B virus, for which interferon-α and nucleoside/nucleotide analogs are currently available but unsatisfactory45. In particular, interferon-α is effective in ...
Metabolic RNA labeling uses 4-thiouridine (4sU) or other nucleoside analogs, which are introduced into living cells and incorporated into nascent RNA. First approaches physically separated labeled and unlabeled RNA by thiol-specific biotinylation and affinity purification and sequenced separate libraries ...
Nucleotide selectivity is at the heart of the problem of understanding the effectiveness of nucleoside analogs used to treat HIV infections, and the evolution of resistance. In order to continue to develop new drugs and most efficiently use the ones available, it will be critical to understand the...
ATP and ATP-ATTO-488 hydrolysis within F-actin was determined by detecting the release of inorganic phosphate with 2-amino-6-mercapto-7-methylpurine ribonucleoside (MESG) and purine-nucleoside phosphorylase (PNP) (Enzcheck, Thermoscientific). We first mixed G-Actin with profilin and ADF/cofilin ...