It was aimed to determine treatment adherence to nucleoside/nucleotide analogs and factors influencing on adherence. Methods: The study included 168 patients who received oral nucleoside/nucleotide analog with diagnosis of chronic hepatitis for at least 1 year. Data regarding demograph...
For other patients, nucleoside or nucleotide analogs should be considered, although “at this stage lamivudine probably doesn’t have much of a role as a first-line treatment, and adefovir is losing favor, as it appears to be not very potent and it is slow to act,” he...
With over 30 drugs approved for the treatment of serious viral diseases, nucleotide and nucleoside analogs that function by targeting viral DNA or RNA polymerases represent one of the largest classes of antiviral drugs. β-d-N4-Hydroxycytidine and its prodrug EIDD-2801, which has been recently app...
Nucleoside analogs are one of the most important classes of antivirals that target the highly conserved active site of viral polymerase and function by being incorporated into new viral genomes to cause defective genomes [10,11]. These kinds of antiviral drugs are characterized with high efficacy a...
Painter Development of hexadecyloxypropyl tenofovir (CMX157) for treatment of infection caused by wild-type and nucleoside/nucleotide-resistant HIV Antimicrob. Agents Chemother., 54 (2010), pp. 2901-2909 View in ScopusGoogle Scholar Laurence et al., 2009 C. Laurence, K.A. Brame...
There is a need for an antiviral that is efficacious when administered during frank diseases; however, none are currently licensed or approved for emergency use. CDV is a nucleotide analogue that selectively inhibits viral DNA polymerase and has been shown to be highly efficacious against most, ...
Wiens A, Lenzi L, Venson R, Correr CJ, Rotta I, Pedroso ML, et al. Comparative efficacy of oral nucleoside or nucleotide analog monotherapy used in chronic hepatitis B: a mixed- treatment comparison meta-analysis. Pharmacotherapy 2013;33:144-151...
Exposure to nucleotide analogues, compared with nucleoside analogs, increased the risk of hip fracture (HR=5.69; 95% confidence interval: 1.98-16.39; P=0.001), but not other events (HR=0.58-1.44; P = 0.202-0.823). CONCLUSIONS: NA treatment does not increase the risk of renal and bone ...
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV
Nucleoside diphosphate kinasenm23Phosphoglycerate kinaseAntiviral nucleoside and nucleotide analogs, essential for the treatment of viral infections in the absence of efficient vaccines, are prodrug forms of the active compounds that target the viral DNA polymerase or reverse transcriptase. The activation ...