Nuclear respiratory factorOxidative stress? 2024 Elsevier B.V.In recent years, the acronym NRF2 has garnered significant attention in scientific discourse. However, this attention has occasionally led to confusion due to the existence of two distinct proteins sharing the same acronym: Nuclear ...
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The purpose of this research was to explore the molecular mechanisms regarding the beneficial efficacy of EA in the rat model of MCAO/R-induced brain injury, and it was found that EA could prevent neuronal ferroptosis after ischemic stroke by facilitating the Nrf2 nuclear translocation and activatin...
Nrf2 nuclear translocation and Nrf2-dependent cytoprotective enzyme induction was observed. The effects of 7R-ETGE on RANKL-dependent induction of intracellular ROS levels and osteoclastogenesis were examined. Finally, the protective effect of 7R-ETGE on RANKL-mediated bone destruction was investigated ...
英文名:NRF2 (Nuclear Factor erythroid 2-Related Factor 2, NF-E2-Related Factor 2, NFE2-Related Factor 2, HEBP1, NFE2L2, NRF2) 中文名: CBNumber:CB04934604 分子式: 分子量:0 MOL File:Mol file NRF2 (Nuclear Factor erythroid 2-Related Factor 2, NF-E2-Related Factor 2, NFE2-Related Fact...
Nox4 was 5-fold higher at wk 7 than at wk 1 while Nrf2 nuclear content and DNA binding ability were 2-fold higher. Results show that prolonged fasting activates the adaptive response to oxidative stress in elephant seals and suggest that Ang II and TGF-尾 stimulate Nox4, which may ...
Our aim was to investigate the role of the Nrf2 and PGC-1 α , the central transcription factors of the regulation of cellular detoxification and defense against oxidative stress, in corneas of double knockout mice (Nrf2-/PGC1 α -). Methods After fixation in 4% PFA, eyeballs were ...
Abstract Despite the number of extensive studies on the immune function and signaling of inflammasomes in various diseases, the activating mechanism of inflammasome, especially the NLRP3 inflammasome, is not fully understood. Nuclear factor E2-related Factor-2 (Nrf2), a key transcription factor that ...
Although nuclear factor E2-related factor-2 (Nrf2) protects from carcinogen-induced tumorigenesis, underlying the rationale for using Nrf2 inducers in chemoprevention, this antioxidative transcription factor may also act as a proto-oncogene. Thus, an enhanced Nrf2 activity promotes formation and chemoresis...