? 2024 Elsevier B.V.In recent years, the acronym NRF2 has garnered significant attention in scientific discourse. However, this attention has occasionally led to confusion due to the existence of two distinct proteins sharing the same acronym: Nuclear Respiratory Factor 2 (NRF2), also known as ...
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7R-ETGE dose-dependently induced nuclear Nrf2, followed by the induction of cytoprotective enzyme expression at both the gene and protein level. 7R-ETGE inhibited upregulation of intracellular ROS levels by RANKL stimulation, and osteoclastogenesis was attenuated. Of particular interest was that local...
To test the hypothesis that Nrf2 is activated in response to prolonged fasting in elephant seals, angiotensin II (Ang II) and TGF-尾 circulating concentrations, along with NADPH oxidase 4 (Nox4) mRNA expression and Nrf2 nuclear content and DNA binding ability, were measured in blood and muscle...
Abstract Despite the number of extensive studies on the immune function and signaling of inflammasomes in various diseases, the activating mechanism of inflammasome, especially the NLRP3 inflammasome, is not fully understood. Nuclear factor E2-related Factor-2 (Nrf2), a key transcription factor that ...
Nrf2 dissociates from Keap1, translocates to the nucleus and activates the transcription of the ARE. The ARE transcribes and drives a variety of antioxidant genes, including heme oxygenase-1 (HO-1), to exert antioxidant effects [34,35,36,37,38]. As a transcription factor, Nrf2 can directly...
2 reagents referenced in Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: a novel mechanism of cellular adaption to inflammatory stress.
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