Another large protein–membrane assembly at the subcellular scale is thenuclear pore complex(NPC)[94•,95], located in the double bilayers of thenuclear envelopemediating particle exchange between nucleus and cytoplasm. Nsp1, anuclear poreprotein, is the major component of NPC.MDsimulations, perfo...
A post-translational modification that is attached to many FG-repeat-containing nucleoporins (FG-NUPs) by the enzyme O-GlcNAc transferase. Epitope tagging A technique in which a known epitope (for example, encoding an affinity tag) is fused to a bait protein, making it possible to detect ...
NSL complex acetylates Lamin A/C The non-specific lethal (NSL) complex is a highly conserved MOF acetyltransferase-containing complex. A recent study now shows that the NSL complex acetylates a new non-histone target, Lamin A/C and reveals the NSL complex as a crucial factor in maintaining ...
Intranuclear filaments containing a nuclear pore complex protein - Cordes, Reidenbach, et al. - 1993Cordes, V.C., Reidenbach, S., Ko¨ hler, A., Stuurman, N., van Driel, R., and Franke, W.W. (1993). Intranuclear filaments containing a nuclear pore complex protein. J. Cell Biol....
The deduced BjCBP20 protein has predicted molecular weight of 29.7 kDa and pI of 6.38, inferred using ProtParam tool. The cap binding protein subunit 2 (CBP20) of the nuclear cap binding complex (CBC) binds to the m7GpppN ‘cap structure’ of the nascent mRNA. By binding co-...
This complex was affinity purified from cells expressing a functional Nup53p-protein A chimera. The localization of Nup53p, Nup59p, and Nup170p within the NPC by immunoelectron microscopy suggests that the Nup53p-containing complex is positioned on both the cytoplasmic and nucleoplasmic faces of...
11. The nucleoprotein complex consisting of CRISPR coded RNAs (crRNAs), trans-activating crRNAs (tracrRNA) and Cas proteins, recognize foreign DNA by the crRNA sequences and degrade it by endonuclease activity12. It is noteworthy that the combination of the humanized Cas9 (hCas9) protein with ...
Co-crystallization of the human nuclear cap-binding complex with a m7GpppG cap analogue using protein engineering. ref A, Mattaj IW, Cusack S (2002) Co-crystallization of the human nuclear cap-binding complex with a m7GpppG cap analogue using protein engineering. ... C Mazza,A Segref,IW...
Koroleva OA, Calder G, Pendle AF, Kim SH, Lewandowska D, Simpson CG, Jones IM, Brown JWS, Shaw PJ: Dynamic Behavior of Arabidopsis eIF4A-III, Putative Core Protein of Exon Junction Complex: Fast Relocation to Nucleolus and Splicing Speckles under Hypoxia. Plant Cell. 2009, 21: 1592-1606...
Targeting and function in mRNA export of nuclear pore complex protein Nup153. J. Cell Biol. 134, 1141–1156 (1996). Article CAS PubMed Google Scholar Merkenschlager, M. & Odom, D. T. CTCF and cohesin: linking gene regulatory elements with their targets. Cell 152, 1285–1297 (2013)....