This, along with our results showing that LumB-like tumors present lower NPDCD4 positivity than LumA-like tumors, suggests that NPDCD4 loss contributes to endocrine therapy resistance in LumB-like BCs. We also revealed that PR induces PDCD4 transcription in LumB-like BC, providing a mechanistic ...
Immunohistochemistry (IHC) was performed on all human colon cancer samples and xenograft tumour tissues using biotin-streptavidin HRP detection systems. Each sample was assigned an IHC score based on the multiplied result of percentage positivity and staining intensity, and total scores ranged from 0 ...
A physiological manoeuvre to improve the positivity of the gastro-oesophageal reflux scintigraphic test Braga, FJHNMiranda, JRDArbex, MAHaddad, JFerro, SZde Oliveira, RBFerriolli, E 521-524 Utility of ventilation and perfusion scan in the diagnosis of young military recruits with an incidental...
FOXO4-DAPI positivity (as a readout for nuclear FOXO4) in each treatment group was quantified by automatic particle counting function of the FIJI Image J software. (e) Quantitation of immunofluorescence from drug-treated cells. Data obtained for the LMB+D4476 and LMB+Bortezomib (Bort) cohorts ...
Previously, we could show that TRAIL-R2 expression was highly correlated with TRAIL-R4 positivity in breast cancer [22]. TRAIL-R4 overexpression correlated with poorer survival in breast [22] and prostate cancer [43]. Applying TRAIL-R2-specific agonists (e.g. the TRAIL-R2-specific antibody ...
Furthermore vimentin positivity was significantly associated with high PCNA index ( P = 0.002). With univariate analysis vimentin positivity and high PCNA index (> 28) were both significantly correlated with shorter disease free survival ( P = 0.003 and P = 0.002 respectively) (median follow-up ...
Ga-PSMA-positivity from CT imaging alone. Sci Rep. 2020;10:3398. Papp L, Spielvogel CP, Grubmüller B, Grahovac M, Krajnc D, Ecsedi B, et al. Supervised machine learning enables non-invasive lesion characterization in primary prostate cancer with [68Ga]Ga-PSMA-11 PET/MRI. Eur J Nucl ...
(B). TFE3 showed moderate to strong nuclear positivity in one case of sclerosing stromal tumor. (C and G). TFE3 was moderately expressed. (E). TFE3 was weakly expressed. Additional file 2 : Fig. S2. External control of TFE3 immunohistochemistry. The negative control was prostate cancer....
Nuclear positivity was recorded using a conventional Olympus BX41 microscope (Olympus, Tokyo, Japan), and defined as negative (0% of cells with nuclear staining), low (1–19% of cells with nuclear staining) or high (X20% of cells with nuclear staining) expression. For immunofluorescence, ...
The nuclear expression of RBM3 in breast cancer was associated with low grade (Po0.001), small tumors (Po0.001), estrogen receptor (ER) positivity (Po0.001) and Ki-67 negativity (Po0.001) in both the breast cancer cohorts. An increased nuclear expression of RBM3 was associated with a ...