Lin J-r HuJ (2013) SeqNLS: nuclear localization signal prediction based on frequent pattern mining and linear motif scoring. PLoS One 8(10):e76864 CentralLin JR, Hu J. SeqNLS: nuclear localization signal prediction based on frequent pattern mining and linear motif scoring. PLoS One 2013;8...
Nuclear localization signals (NLSs) are stretches of residues in proteins mediating their importing into the nucleus. NLSs are known to have diverse patterns, of which only a limited number are covered by currently known NLS motifs. Here we propose a sequential pattern mining algorithm SeqNLS to...
Nuclear localization sequence (NLS) Nucleo-cytoplasmic transport Prediction of nuclear localization Transportin-1/karyopherin-β2 Sorry, something went wrong. Please try again and make sure cookies are enabledCited by (0)☆ This article is part of a Special Issue entitled: Regulation of Signaling an...
BMCBioinformaticsBioMedCentralResearcharticleOpenAccessNLStradamus:asimpleHiddenMarkovModelfornuclearlocalizationsignalpredictionAlexNNguyenBa1,2,AnastassiaPogoutse1,NicholasProvart1,2andAlanMMoses*1,2Address:1DepartmentofCell&SystemsBiology,UniversityofToronto,25WillcocksStreet,Toronto,Canadaand2CentrefortheAnalysisof...
A variety of nuclear localization signals (NLSs) are experimentally known although only one motif was available for database searches through PROSITE. We initially collected a set of 91 experimentally verified NLSs from the literature. Through iterated 'in silico mutagenesis' we then extended the se...
Keywords: Position Specific Scoring Matrix; Auto Covariance; Support Vector Machine; Protein Subnuclear Localization Predictiondoi:10.4236/jbise.2009.21009Rong-Quan XiaoYan-Zhi GuoYu-Hong ZengHai-Feng TanXue-Mei PuMeng-Long LiScientific ResearchJournal of Biomedical Science and Engineering...
although it does not seem to be present in the nucleoli. A search for the Nuclear Localization Signal (http://nls-mapper.iab.keio.ac.jp/cgi-bin/NLS_Mapper_form.cgi24) in the HuP10 sequence predicted a signal at aa positions 64–74 of the protein (Supplementary Figure S1A), which is...
NLStradamus: a simple Hidden Markov Model for nuclear localization signal prediction. BMC Bioinform. 2009;10:202. Article CAS Google Scholar Kalderon D, Roberts BL, Richardson WD, Smith AE. A short amino acid sequence able to specify nuclear location. Cell. 1984;39(3):499. Article CAS ...
Identification of a nuclear localization sequence within the structure of the human interleukin-1 alpha precursor. J. Biol. Chem. 268, 22100–22104 (1993). Article CAS PubMed Google Scholar Luheshi, N. M., Rothwell, N. J. & Brough, D. The dynamics and mechanisms of interleukin-1alpha ...
Fig. 4: Mapping of nuclear localization signal sites in RFPL3. A The predicted nuclear localization sequences of RFPL3 using bioinformatics software cNLS Mapper. B Schematic of RFPL3 protein and its truncation mutants tagged with FLAG. C A549 cells transfected with RFPL3-FLAG-conjugated plasmids...