Without question, ABL capabilities are encoded by its gene sequence and that molecular blueprint designs this kinase to be regulated by subcellular location-dependent interactions with inhibitors and substrate activators. Furthermore, ABL shuttles between the nucleus and the cytoplasm where it binds DNA...
transcribing HIV RNA but do not produce infectious virus particles [3,29]. A question then arises of whether the active reservoir is a true reservoir, in other words how would such cells persist for a long time and escape immune-mediated killing. One simple possibility is that no viral prote...
aA single sequence context cannot satisfy all non-AUG initiator codons in yeast 唯一序列上下文在酵母不可能满足所有非8月创始者密码子[translate] aillustrate how shallow dreamless sleep is 说明怎么浅无梦睡眠是[translate] aHi This is kate 喂这是kate[translate] ...
The localization of AtTPS genes on all five chromosomes reflects the dynamics of the Arabidopsis genome; however, several AtTPS genes are clustered and ... S Aubourg,A Lecharny,J Bohlmann - 《Molecular Genetics & Genomics》 被引量: 694发表: 2002年 Stochastic genome-nuclear lamina interactions ...
sequences in the entire genome, targeted DNA regions, or RNA fractions in a significantly shorter time compared to the first-generation technology of automated Sanger sequencing [86]. NGS allows for whole-genome sequencing to be completed within a single day, whereas the sequencing of the human ...
The presence of germline MEN1 mutations should be considered a possibility in very young patients with isolated sporadic pituitary adenomas when AIP mutation screening is negative Both AIP and MEN1 are considered to be tumour suppressor genes and might act via regulators of the cell cycle and/or ...
Whereas it is widely accepted that the transit peptide of the precursor for the light-harvesting chlorophyll a/b protein (preLHCP) is responsible for targeting this polypeptide to chloroplasts, the signals which govern its intraorganellar targeting appears to be transit peptide-mediated for plastocyanin...
This proportion is surprisingly low given the high abundance of these sequences in human genome (45%) and reveals that the amount of TEs is not related to the activity. Barbara McClintock in the early 1980s proposed that TEs could be activated by a genomic shock, and this might have an ...
What: AD is uniquely human, but molecular mechanisms can be measured in Tg mice. • Who: A universal biological variable of AD, APOE is critical for preclinical models. • How: There are several strategies for developing APOE-Tg mice. • When/Where: Developmental and region-specific mode...
The lncRNA MALAT1 has an ENE+A structure and an METTL16 recognition sequence, allowing it to interact directly with METTL16 [24]. Studies have shown that MALAT1 can both facilitate and suppress cancer development and is common in various cancers [71,72]. An analysis of 89 pathways in 64...