(1997) Sequence determinants for hnRNP I protein nuclear localization. Esp. Cell. Res. 235, 300-304.Romanelli MG, Weighardt F, Biamonti G, Riva S, Morandi C. Sequence determinants for hnRNP I protein nuclear lo
(i) the classical pathway, which involves the classical nuclear localization sequences (cNLSs) and the receptors importin-α/karyopherin-α and importin-β/karyopherin-β1; and (ii) the karyopherin-β2 pathway, which employs the proline-tyrosine (PY)-NLSs and the receptor transportin-1/...
L. et al. Novel low molecular weight microtubule-associated protein- 2 isoforms contain a functional nuclear localization sequence. J. Biol. Chem. 274, 19261–19268 (1999). 30. Wittke, I., Madge, B., Wiedemeyer, R., Kimchi, A. & Schwab, M. DAP-5 is involved in MycN/IFNgamma-...
The mechanism for nuclear envelope (NE) assembly is not fully understood. Importin-β and the small GTPase Ran have been implicated in the spatial regulation of NE assembly process. Here we report that chromatin-bound NLS (nuclear localization sequence)
核定位信号 Nuclear localization sequence(NLS)Nuclear localization sequence A nuclear localization signal or sequence(NLS)is an amino acid sequence that'tags’a protein for import into the cell nucleus by nuclear transport.Typically,this sig-nal consists of one or more short sequences of positively ...
Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus. This NLS-dependent protein recognition, a process necessary for cargo proteins to p
proteins increasing binding in the K+buffer overlaps with the previously annotated K-562 nuclear interactome, whereas only a single protein depleted in K+buffer does, showing that enrichment of binding in response to K+to stabilized G4 RNA sequences supports an annotation as true RBPs (Fig.3d...
After verification, some of them have nuclear localization function, while others do not. For example, a PY-NLS-like sequence was predicted to be encoded by residues 259–306 of poly(A) Lu et al. Cell Commun Signal (2021) 19:60 Page 4 of 10 binding protein nuclear 1 (PABPN1). ...
After verification, some of them have nuclear localization function, while others do not. For example, a PY-NLS-like sequence was predicted to be encoded by residues 259–306 of poly(A) Lu et al. Cell Commun Signal (2021) 19:60 Page 4 of 10 binding protein nuclear 1 (PABPN1). ...
LocNucleicombined homology-based inference and machine learning-basedde novopredictions in the same way LocTree3 [13] does: if a sequence similar to a protein of experimentally known localization is available that annotation is transferred, if not, the machine learning-based prediction is returned. ...