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Androgen deprivation therapy (ADT) targeting androgen/androgen receptor (AR)- signaling pathways is the main therapy for advanced prostate cancer (PCa). However, ADT eventually fails in most patients who consequently develop castration-resistant prostate
Owing to its substantial involvement in the development of cancer cells, TOP2B has become a prospective target for anti-cancer therapy. Several anti-cancer drugs, including TOP2B inhibitors, can restrict the replication of DNA and impede the repair mechanisms of cancer cells, ultimately resulting ...
In vivomouse models have proven invaluable for assessing SRC-3′s role in breast cancer. Amouse mammary tumor virus(MMTV) LTR-driven SRC-3transgenic mousewas created to specifically overexpress SRC-3 in the mammary tissue of mice (Torres-Arzayus et al., 2004). In this model, there was a...
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Somatic cell nuclear transfer followed by CRIPSR/Cas9 microinjection results in highly efficient genome editing in cloned pigs. International ... P Timothy,Park,ChiHun,... 被引量: 7发表: 2016年 molecular sciences communication somatic cell nuclear transfer followed by cripsr/cas9 microinjection ...
Although evasion of apoptosis is thought to be required for the development of cancer, it is unclear which cell death pathways are evaded. We previously id... J Thorburn,F Moore,A Rao,... 被引量: 293发表: 2005年 Tissue inhibitor of metalloproteinases protect blood-brain barrier disruption in...
Nuclear localization is essential for the tumor suppressive role of PTEN, as a PTEN mutant deficient in nuclear import but with intact phosphatase activity causes Cowden syndrome22, and the absence of nuclear PTEN was associated with more aggressive cancers22,23,24,25,26. Intriguingly, it has lon...
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