Nuclear inhibitor of protein phosphatase 1 (NIPP1)TauPhosphorylationMyelinationCompound action potential (CAP)Knockout mouseMolecular Neurobiology - Nuclear inhibitor of protein phosphatase 1 (NIPP1) is a known regulator of gene expression and plays roles in many physiological or pathological processes ...
Recent work has revealed essential roles for Ser/Thr phosphatases, such as protein phosphatase-1 (PP1), in splicing, but how these phosphatases are regulated is largely unknown. We show that nuclear inhibitor of PP1 (NIPP1), a major PP1 interactor in the vertebrate nucleus, recruits PP1 ...
Protein phosphatase 1 is a key player in nuclear events Among them are PNUTS (phosphatase 1 nuclear targeting subunit), NIPP1 (nuclear inhibitor of PP1) and CREB (cAMP-responsive element-binding protein), ... S Rebelo,M Santos,F Martins,... - 《Cellular Signalling》 被引量: 33发表: 201...
These regulatory proteins include several heat-stable inhibitors, such as inhibitor-1, its neuronal homologue DARPP-32, and inhibitor-2, which are controlled by phosphorylation (1, 2). PP1 is also regulated by a family of proteins, termed targeting subunits, that direct the catalytic subunit of...
The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib. Tumor cells are characterized by uncontrolled proliferation, often driven by activation of oncogenes, and apoptosis resistance. The oncogenic kinase inhibi... H Hikita,T...
Regulation of protein tyrosine phosphatase 1B by sumoylation It is unclear how the activity of PTP1B is regulated. Using a yeast two-hybrid assay, a protein inhibitor of activated STAT1 (PIAS1) was isolated ... S Dadke,S Cotteret,SC Yip,... - 《Nature Cell Biology》 被引量: 226发...
To increase the oxidative level, BECs/HPCs were exposed to reactive species with different action: H2O2 (simplest peroxide, strong oxidizer, second messenger), tert-butyl hydroperoxide (t-BuOOH, organic peroxide, strong oxidizer), buthionine sulfoximine (BSO, inhibitor of glutathione synthesis), and...
to major human diseases such as cancer, neurodegenerative diseases, and viral infections. Selinexor (KPT-330), an inhibitor targeting the nuclear export factor XPO1 (also known as CRM1), was approved in 2019 to treat two types of blood cancers, and dozens of clinical trials of are ongoing....
From the Cyclooxygenase-2 Inhibitor Celecoxib to a Novel Class of 3-Phosphoinositide-Dependent Protein Kinase-1 Inhibitors The blockade of Akt activation through the inhibition of 3-phosphoinositide-dependent kinase-1 (PDK-1) represents a major signaling mechanism whereby celec... J Zhu,JW Huang,PH...
(LMW) FGF2 shows that it does not have classical NLS sequence, but the apoptosis inhibitor 5 (API5) interacting region of FGF2 overlaps with its cryptic NLS region. The observations that LMW FGF2 is localized mainly in the nucleus when co-expressed with API5, but mainly in the ...