在一些实施方案中,借助于体内药代动力学过程和药物代谢的知识,一旦确定了药学上活性的化合物,就设计化合物的前药。(参见例如,nogrady(1985)medicinalchemistryabiochemicalapproach,oxforduniversitypress,newyork,第388-392页;silverman(1992),theorganicchemistryofdrugdesignanddrugaction,academicpress,inc.,sandiego,第352...
金坚教授课题组的研究方向主要为:(1)组蛋白甲基转移酶选择性抑制剂的发现;(2)G蛋白偶联受体偏向性配体的开发;(3)靶向肿瘤蛋白新型降解剂的研制。迄今为止已在相关领域发表超200篇SCI论文,包括Nature, Science, Cell, Nat. Med., Nat. Rev. D...
NSD蛋白家族是较新识别的一个组蛋白甲基化转移酶家族,在多种疾病,尤其是在肿瘤中常常表达异常。对NSD蛋白家族的研究不仅有助于进一步了解相关肿瘤的发病机制,而且有助于发现新的肿瘤标志物与肿瘤治疗的新靶点,具有潜在和重要的临床应用价值[2]。 一、NSD蛋白家族的结构及生物学功能介绍 1.1 NSD蛋白家族的结构 NSD蛋...
32.Furukawa Y, Kikuchi J. Epigenetic mechanisms of cell adhesion-mediated drug resistance in multiple myeloma.Int J Hematol. 2016;104:281-292.[PubMed][DOI] 33.Xie Z, Chng WJ. MMSET: role and therapeutic opportunities in multiple myeloma.Biomed Res Int. 2014;2014:636514.[PubMed][DOI]...
该研究揭示了NSD2通过与AuroraA形成蛋白翻译后相互修饰的正性调控环路,促进耐药相关基因转录激活的分子机制,相关研究成果于近日在线发表在《Clin Transl Med》,题目为“Posttranslational modification of Aurora A-NSD2 loop contributes ...
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To determine the synergy between two drug treatments, cells were treated with increasing concentrations of either drug for 120 h, followed by the determination of viable cells using the CellTiter-Glo Luminescent Cell Viability Assay (Promega). The experiment was carried out in four biological repli...
Who is responsible for cellular phone safety in this country? In the United States, both the federal government and state agencies have that responsibility. Which ones? On the federal level, the Food and Drug Administration (FDA), the Federal Communications Commission (FCC), and the Occupational...
Further, NSDs might be attractive targets for drug development, and targeting NSD1/NSD2 enzymes may be a new strategy for improving outcomes in HNSCC patients.Iuliia TopchuRajendra PangeniIgor BychkovPetr MakhovJohn KaranicolasJindan YuErica Golemis...
BackgroundThe ideal malaria parasite populations for initial mapping of genomic regions contributing to phenotypes such as drug resistance and virulence, t... P Orjuela-Sánchez,ND Karunaweera,MD Silva-Nunes,... - 《Bmc Genetics》 被引量: 79发表: 2010年 Single-nucleotide polymorphism, linkage di...