High frequency gene mutations were screened based on different PDL1 expressions. Moreover, the log rank test was applied to analyze the overall survival (OS) difference based on different gene mutation types. Results A total of 838 patients with NSCLC were included in our study. White patients ...
Clinicopathologic characteristics of the EGFR gene mutation in non-small cell lung cancer. The authors sought to define clinicopathologic features associated with mutations of the epidermal growth factor receptor (EGFR) gene in non鈥搒mall cell l... AS Tsao,MT Xi,B Sabloff,... - 《Journal of...
ThechangesofCA125andCYFRA21—1mayberelatedtothegenemutationof EGFR.andserUmCEAlevelisrelatedtotheEGFRmutationtypes.CAl25.CYFRA21—1andserumCEAlevelcanbeusedas potentialserologicalindicatorsofta~ettherapyefi cacy,worthyoffurtherclinicalstudy. KeyWords:NSCLC;Epidermalgrowthfactorreceptor;Tumorrharkers ...
10.Kasi PM, Lee JK, Pasquina LW, et al. Circulating tumor DNA enables sensitive detection of actionable gene fusions and rearrangements across cancer types.Clin Cancer Res. 2024;30(4):836-848. 11.Li W, Guo L, Liu ...
(EGFR) gene mutation and anaplastic lymphoma kinase (ALK) gene rearrangement. Subgroup analyses were performed on the basis of cell types and molecular markers. The χ2 test was performed to compare the diagnostic yields, and Bonferroni correction was used...
Even for those rare driver mutations, the efficacy of immunotherapy varied among different mutation types and clinicopathological status such as smoking and tumor mutation burden (TMB), showing significantly inferior response rate to targeted therapies7. The mechanism that caused impaired efficacy in ...
Moreover, the log rank test was applied to analyze the overall survival (OS) difference based on different gene mutation types. Results A total of 838 patients with NSCLC were included in our study. White patients are more likely to have PDL1 ≥ 1% (P = 0.004). ERBB4, EP300, PREX2,...
Exon 19 deletions were detected in 49 patients, exon 21 point mutations (L858R) were detected in 22 patients, and both mutation types were detected in 2 patients. An increased incidence of EGFR mutations among patients with adenocarcinoma (14.9% vs 7.8%, p = 0.008), women (20.2% vs 7.1%...
在高水平的PD-L1或非同义肿瘤突变压力(tumor mutation burden,TMB)下,ICB的单一疗法比较有效,可是若T细胞数较少或较低的TMB,或许应该选择另一种方案诱导免疫原型的肿瘤细胞死亡,如细胞毒疗法、表观遗传修饰或溶瘤病毒法目前在临床前...
gene mutation (1%-4% of cases), gene amplification (2%-5%) and protein overexpression (2%-30%), with different prognostic and predictive outcomes. So far, non-selective tyrosine kinase inhibitors (TKIs) have shown a minor benefit in HER2-mutant NSCLC patients with objective response rates (OR...