还有报道称,在宫颈癌患者的肿瘤引流淋巴结(TDLN)中,NRP1+Treg细胞增多,尤其是肿瘤转移的TDLN。此外,人NRP1+Treg细胞的功能更为抑制,FOXP3和糖皮质激素诱导的TNFR相关蛋白(GITR)在NRP1+Treg细胞中的表达增加。有趣的是,针对VEGF结合域的NRP1拮抗剂通过诱导NRP1蛋白内化,使人肿瘤内Treg细胞抑制降低约20%。最后,...
结论高剂量电离辐射可以诱导小鼠胸腺细胞中NRP1+Treg细胞表达并增加TGF—B1的含量,此现象可能与启动PLC/PIP2信号通路有关。 参考资料: Mayer CT, Floess S, Baru AM, et al. CD8 + Foxp3 + T cells share developmental and phenotypic features with classical CD4 + Foxp3 + regulatory T cells but lack ...
nrp1可增强天然调节性t细胞(natural treg)的免疫抑制功能,可抑制肿 瘤浸润cd8 + 记忆性t细胞的分化。因此,nrp1抑制抗肿瘤免疫应答。此外, nrp1被发现表达在ilc3上并促进人ilc3的迁移(32,33)。但nrp1是否表达在 ilc2上以及是否对ilc2的功能有调节作用未有报道。 19.nrp1与sars-cov-2感染病理过程相关 20.患者...
regulatory T cellstrokeBackground and Purpose Adoptive transfer of regulatory T cells (Tregs) protect against stroke; however, Treg-based therapy raises concerns in stroke patients with cancer because of the immunosuppressive function of Tregs. The purpose of this study was to investigate the role ...
Objective The purpose of the present study was to observe the changes in CD4+CD25+Nrp1+Treg cells after irradiation with different doses and explore the po... Juan,Cong,DONG,... - 《Biomedical and Environmental Sciences》 被引量: 17发表: 2014年 加载更多站...
We have shown that the immune cell surface ligand semaphorin-4a (Sema4a) on conventional T cells and DCs, and the Treg-restricted receptor neuropilin-1 (Nrp1) interact to potentiate Treg function. Mice with a Treg-restricted deletion... DA Vignali - 《Cancer Immunology Research》 被引量: 53...
Stomach adenocarcinoma (STAD) is the most common type of gastric cancer (GC), with a high recurrence rate and poor prognosis, but the potential indicators for STAD are insufficient. Herein, we found that MicroRNA-378c (miR-378c) was lowly expressed in ST
这些 高度保守的调节且混杂的T细胞表位被称为调节T细胞表位(Tregitopes)(De Groot等人, Blood.2008年10月15日;112(8):3303‑11)。可在大量调节T细胞表位存在下有效地控制人 源化抗体中所含有的新表位的免疫原性潜能。 [0266] 出于抗体免疫原性分析的目的,EpiVax包括经调节T细胞表位调节的EpiMatrix分 数及抗治疗...
近年来研究发现,Foxp3不仅仅表达于Treg,而在某些实体肿瘤组织和细胞中也存在不同程度的表达。免疫组化染色结果显示,肿瘤组织内Treg和肿瘤细胞均表达Foxp3。79.3%的印戒细胞癌患者存在Foxp3表达,且Foxp3表达与淋巴结转移显著相关。肿瘤细胞中Foxp3表达可能在胃癌免疫逃逸过程中扮演重要作用,并与胃硬癌的恶性潜能相关[6...
The present invention relates to a composition for inhibiting the immunosuppression of regulatory T cells (Treg), using a fusion protein inclusive of a peptide binding specifically to neuropilin 1 (NRP1). The fusion protein inclusive of the peptide binding specifically to neuropilin 1 according to ...