这个基因是neuregulin基因家族的一员这个基因家族编码跨膜酪氨酸激酶受体ERBB3和erb4的配体-表皮生长因子受体家族的成员配体结合激活细胞内信号级联和诱导细胞反应,包括增殖、迁移、分化和存活或凋亡。这个基因编码神经调节蛋白3(nrg3)。NRG3已被证明能激活其同源受体ERBB4的酪氨酸磷酸化,并被认为通过ERBB4的信号传导影响...
这个基因是neuregulin基因家族的一员这个基因家族编码跨膜酪氨酸激酶受体ERBB3和erb4的配体-表皮生长因子受体家族的成员配体结合激活细胞内信号级联和诱导细胞反应,包括增殖、迁移、分化和存活或凋亡。这个基因编码神经调节蛋白3(nrg3)。NRG3已被证明能激活其同源受体ERBB4的酪氨酸磷酸化,并被认为通过ERBB4的信号传导影响...
这个基因是neuregulin基因家族的一员这个基因家族编码跨膜酪氨酸激酶受体ERBB3和erb4的配体-表皮生长因子受体家族的成员配体结合激活细胞内信号级联和诱导细胞反应,包括增殖、迁移、分化和存活或凋亡。这个基因编码神经调节蛋白3(nrg3)。NRG3已被证明能激活其同源受体ERBB4的酪氨酸磷酸化,并被认为通过ERBB4的信号传导影响...
NRG3抗体直接配位体用于ERBB4酪氨酸激酶受体。结合刺激酪氨酸的酪氨酸磷酸化和受体的激活。NRG3抗体不与EGF受体,ERBB2或ERBB3受体结合。可能是寡突细胞的生存因子。 NRG3抗体 的详细介绍 英文名称:NRG3抗体 中文名称神经调节蛋白3抗体 别名HRG3; Neuregulin 3; Neuregulin 3 like polypeptide; Neuregulin-3; ...
Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. Proc Natl Acad Sci USA 1997;94:9562-9567.Zhang D, Sliwkowski MX, Mark M, Frantz G, Akita R, Sun Y, Hillan K, Crowley C, Brush J, Godowski PJ. Neuregulin-3 (NRG3): a novel neural ...
NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this...
Zhang D, Sliwkowski MX, Mark M, Frantz G, Akita R, Sun Y, Godowski PJ (1997) Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. Proc Natl Acad Sci USA 94(18):9562–9567 CrossRef About this Article Title NRG3 gene is associated with th...
The NRG1/ErbB complex promotes postnatal maintenance of the ENS and neuronal survival through other biological functions10,29. As a paralog of the NRG1 analogue, NRG3 shares the same receptor, ErbB4, with NRG1, and both genes may play important roles in the development of the embryonic ...
Description Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. Cell Pathway/ Category Primary ...
目的探讨氯胺酮连续给药致小鼠产生的类似精神分裂症症状,与精神分裂症易感基因神经调节蛋白1(neuregulin-1,NRG1)及其受体ErbB4 mRNA表达的相关性,为研究精神分裂症的可能发病机制提供参考依据。方法50只雄性昆明种小鼠,随机分为生理盐水组、氯胺酮小剂量(25 mg/kg)、中剂量(50 mg/kg)、大剂量(100 mg/kg)组和氯...