such as infection, trauma, and inhalation of harmful substances [57]. The pathological process of ALI involves extensive lung tissue damage and dysfunction, and is therefore more appropriately regarded as a clinical syndrome of acute lung injury rather than a stand-alone chronic lung disease [58]....
For example, Feprazone, a non-steroidal anti-inflammatory drug and COX inhibitor, has been shown to increase the transcription of Nrf2, which reduces the production of ROS and inhibits the IL-1β induced NF-κB signaling cascade in chondrocytes [211]. Other drugs that have been determined to...
Dietary L. reuteri-derived metabolites contribute to immune checkpoint inhibitor therapy in melanoma [36]. Supplementation of L. reuteri with the ability to produce Aryl hydrocarbon receptor (AhR) ligands ameliorated E. coli-induced mastitis in an AhR-dependent manner [37]. In this study, L. ...
1. Peking University School of Pharmaceutical Sciences, Department of Molecular and Cellular Pharmacology, Beijing 100191, China; 2. Drug Clinical Trial Institution, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi 214023,...
Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. Sulforaphane is also an inhibitor of histone deacetylase (HDAC) and
CO acts as an inhibitor of the NF-ĸB pathway which leads to the decreased expression of pro-inflammatory cytokines, while bilirubin also acts as antioxidant. Furthermore, HO-1 directly inhibits the proinflammatory cytokines as well as activating the anti-inflammatory cytokines, thus leads to ...
In sum, curcumin has been widely used as NRF2 activator and inflammatory inhibitor, which makes curcumin a promising anti-cancer dietary phytochemical [74]. Sulforaphane Sulforaphane belongs to the sulfur-containing glucosinolates class of dietary phytochemicals, present in a wide variety of plant ...
方法 构建 TGF-β1 诱导的 NRK-52E 细胞转分化 模型,分别使用 miR-23b-5p mimic,inhibitor 以及阴性对照(NC)siRNA 转染细胞;采用清肾颗粒含药血清进行干预,分为正常 组,TGF-β1 组,清肾颗粒组,miR-23b-mimic-NC 组,miR-23b-mimic 组,miR-23b-mimic+清肾颗粒组.采用 CCK8 法测定 NRK- 52E细胞活性;...
Over the last 30 years, NRF2 has evolved from being recognized as a transcription factor primarily involved in redox balance and detoxification to a well-appreciated master regulator of cellular proteostasis, metabolism and iron homeostasis. NRF2 play
as evidenced by significant improvements in clinical metrics such as the arthritis index, behavioural scores and paw thickness in the rats. The researchers further validated these findings using the Nrf2 inhibitor brusatol and the HO-1 inhibitor Znpp, which subsequently reduced cell viability, increased...