Regulatory T cells (Tregs) have a central role in maintaining immune homoeostasis through various mechanisms. Although the Forkhead transcription factor Foxp3 defines the Treg cell lineage and functions, the molecular mechanisms of Foxp3 induction and maintenance remain elusive. Here we show that Foxp...
本申请提供了用于筛查、诊断和/或监测个体中冠心病的组合物或试剂盒及相关用途,所述组合物或试剂盒包含用于检测来自所述个体的样本中NR4A2特异性序列的试剂,包括引物或探针。 (19)国家知识产权局 (12)发明专利申请 (10)申请公布号 CN 115786487 A (43)申请公布日 2023.03.14 (21)申请号 202210930692.4 (22)申...
NR4A receptors are expressed at high levels in CD8+ T cells from humans with cancer or chronic viral infection and are linked to induction of T cell dysfunction (9., 10., 11.). NR4A receptors repress effector gene expression by inhibiting the function of the TF AP-1 and activate ...