Nuclear hormone receptor4a1 (Nr4a1) plays a critical role in β‐cell replication, function, and survival. β‐cell replication is tightly regulated, most β‐cells in the body are formed during development and shortly after birth. Nr4a1 full body knock‐out mice have a 50% reduction in ...
B cell lymphoma gene 2 (Bcl-2) family proteins are key regulators of programmed cell death and important targets for drug discovery. Pro-apoptotic and anti-apoptotic Bcl-2 family proteins reciprocally modulate their activities in large part through protein interactions involving a motif known as BH...
We found a vastly reduced expression of NR4A1 and NR4A3 in chronic lymphocytic B-cell leukemia (71%), in follicular lymphoma (FL, 70%), and in diffuse large B-cell lymphoma (DLBCL, 74%). In aggressive lymphomas (DLBCL and FL grade 3), low NR4A1 expression was significantly associated ...
Next, we performed single-cell transcriptional profiling and found that a CD11c+ macrophage subtype was enriched from Nr4a1−/− laser-treated eyes and expressed a pro-angiogenic transcriptome. These data suggest that non-classical monocytes are dispensable in the laser-induced CNV model and that...
Stress can induce expression of norepinephrine, which can enhance neuroinflammation. Shaked, Hedrick and colleagues show that the transcriptional repressor Nr4a1 limits this stress-induced response by suppressing expression of tyrosine hydroxylase requir
The Nr4a nuclear hormone receptors are transcriptionally upregulated in response to antigen recognition by the T cell receptor (TCR) in the thymus and are implicated in clonal deletion, but the mechanisms by which they operate are not clear. Moreover, their role in central tolerance is obscured...
However, when cancer cells lose the TGF-b tumour suppressive responses, they can utilize TGF-b as a potent promoter of cell motility, invasion, metastasis and tumour stem cell maintenance1,10. NR4A1 (also named Nur77, TR3 or NGF-IB) is a member of the steroid/thyroid hormone receptor ...
However, when cancer cells lose the TGF-b tumour suppressive responses, they can utilize TGF-b as a potent promoter of cell motility, invasion, metastasis and tumour stem cell maintenance1,10. NR4A1 (also named Nur77, TR3 or NGF-IB) is a member of the steroid/thyroid hormone receptor ...
Abstract 2086: ISCVAM, an Interactive Single Cell Visual Analytics for Multiomics, accelerates the identification of novel rare cell populations BACKGROUND Emergent single cell technologies have accelerated the discovery of rare cell populations and characterization of complex tumor microenvironment... TNM ...
Figure 2. Nr4a1/3-null HSCs have increased cell cycle with increased oxidative stress and DNA damage. (A) Ki67 and (B) BrdU incorporation (16 hours in vivo), (C) DNA content analysis after acute NR4A1/3 codepletion. (D) BrdU incorporation analysis in HSCs from wild-type CD45.1 recipie...