nucleophosmin (NPM1) mutationacute myeloid leukemia (AML)menin inhibitorsexportin 1XPO1 inhibitorsminimal residual disease (MRD)CAR-T cellsarsenic trioxideThe nucleophosmin 1 (NPM1) gene is mutated in approximately one-third of newly diagnosed acute myeloid leukemia (AML) cases. NPM1mutated AML (...
有研究报道,按先前标准可分类为MDS或MDS/MPN的病例,如果伴有NPM1突变,大多在短时间内进展为AML[2],图11中列出了文献报道的一例原始细胞<20%的伴NPM1突变的髓系肿瘤在初诊及治疗后两个多月时间内的外周血原始细胞比例的变化。同本病例类似,文献病...
Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin. Leukemia. 2005;19:1760–7. Article CAS Google Scholar Vassiliou GS, Cooper JL, Rad R, Li J, Rice S, Uren A, et al. Mutant nucleophosmin and cooperating pathways drive leukemia initiation ...
3. A study of DSP-5336 in relapsed/refractory AML/ ALL with or without MLL rearrangement or NPM1 mutation. ClinicalTrials.gov. Updated January 18, 2024. Accessed July 15, 2024.
Clinical features of primary AMLs without NPM1 mutation Jiao Yang Authors Info & Affiliations Published: 2017 -12 -11 · DOI: 10.3760/cma.j.issn.1009-9158.2017.12.014624 28 0 0 0 0PDF下载摘要 急性髓系白血病(acute myeloid leukemia,AML)是一种异质性很高的疾病,其发生率大约占成人急性白血病的...
细胞形态学:伴NPM1基因突变的AML患者中常会发现杯口细胞(cup-likecell)。 免疫表型:在一般AML免疫表型基础上CD34、CD117、CD15、CD19、HLA-DR等的表达有不同。 5 NPM1mut·临床特征 MutationofNPM1andFLT3GenesinAcuteMyeloidLeukemiaandTheirAssociationwithClinicalandImmunophenotypicFeatures 6 NPM1mut·细胞形态学...
结论NPM1基因突变与CN-AML高肿瘤负荷以及高诱导化疗缓解率具有相关性。 关键词: 白血病,髓样,急性;基因,NPM1;突变 ABSTRACT ObjectiveTo investigate the frequency of NPM1 mutation and its clinical significance in patients with cytogenetically normal acute myeloid leukemia(CN-AML). MethodsThe data of 190 ...
The emergence of a smallFLT3-ITD subclone (0.5%) at relapse suggests clonal evolution towards a more aggressive AML.FLT3-ITD is an unstable mutation that may be lost (if present at diagnosis) or acquired at relapse. Interestingly, 4/6NPM1-mutated AML patients withFLT3wild-type at diagnosis ...
急性髓系白血病伴NPM1突变常累及NPM1基因的外显子12。胞质异常表达NPM是这一基因突变的替代标志。这类AML常呈粒-单核细胞或单核细胞特征,典型情况下原发存在于正常核型的成人AML。 NPM1 mutation is one of the most common recurrent genetic lesions in A...
Conclusions: 1) DNMT3Amut persist in remission of NPM1mut AML in the majority of cases (59.2 %). 2) DNMT3Amut analysis in remission of NPM1mut AML is an important parameter for prognostication. 3) Clones with DNMT3Amut as the sole mutation may have a normal phenotype and thus DNMT3Amu...