DescriptionNPM1-ALK fusion protein p80 is derived from the fusion of the N-terminal oligomerization domain of NPM1 (1–110 aa) and the C-terminal tyrosine kinase domain of ALK (1058–1620 aa). In these malignancies, the homo-dimerization of NPM1-ALK leads the constitutive activation of a ...
NPM1-ALK价格:元 规格: 10ug 100ug 联系方式:I47-825O-882O立刻购买 买家导航 产品基本信息 基因信息 基因名称: Homo sapiens mRNA for p80 protein, complete cds 物种来源: 人 基因缩写: NPM1-ALK 基因又名: CD246 基因序列号: D45915.1 基因位置 2p23 蛋白信息 蛋白名称: p80 protein [Homo ...
Left Gene NPM1(E4) Left Breakpoint chrt5:1708***9:+ Right Gene ALK(E20) Right Breakpoint chr294***4- Buffer Tris-EDTA Product Information Intended Use Research Use Only Unit Size 1ug Concentration Download for COA Purity Download for COA DNA electrophoresis Download for COA Sanger sequencin...
专利名称:Npm1基因突变检测方法及其试剂盒的制作方法 技术领域:本发明涉及生物技术领域,具体是NPMl基因突变检测方法及其试剂盒。 背景技术:NPMl是一种广泛表达的磷蛋白质,其作用为在细胞核与细胞浆之间穿梭,可与 ALK, RARa和MLF-I等形成融合基因,参与多种白血病或淋巴瘤的发病。近来,多项研究显示46-62%的正常...
英文名字 ALK/NPM1 monoclonal antibody, clone 5A4 供应商 Abnova 产品货号 MAB2086 产品报价 ￥4340/100 uL 产品说明书 点击查看 购买方式 产品新闻 背景资料 应用类型 Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (Formalin/PFA-fixed paraffin-embedded sections) (1:40) ...
如果你对CBP20032RNPM1(E5)-ALK(E20) Fusion 标准品感兴趣,想了解更详细的产品信息,填写下表直接与厂家联系: 产品: 您的单位: 您的姓名: 联系电话: 常用邮箱: 省份: 详细地址: 补充说明: 验证码: 请输入计算结果(填写阿拉伯数字),如:三加四=7 ...
and is the substrate of CDK2/cyclin E during duplication of centrosomes (cellular division). Due to the NPM1 gene interaction with several tumor-associated chromosome translocations, NPM1 is thought to be a portion of several fusion proteins: NPM-ALK, NPM-RAR, and NPM-MLF1. While it is ...
Children with lymphomas driven by NPM1-ALK fusion proteins achieved an objective response rate to ALK inhibition therapy of 54-90% in clinical trials. However, a subset of patients progress within the first 3 months of treatment. The mechanism for the development of ALK inhibitor resistance is ...
and is the substrate of CDK2/cyclin E during duplication of centrosomes (cellular division). Due to the NPM1 gene interaction with several tumor-associated chromosome translocations, NPM1 is thought to be a portion of several fusion proteins: NPM-ALK, NPM-RAR, and NPM-MLF1. While it is ...
regulation of DNA polymerase alpha activity, centrosome duplication and molecular chaperoning activities. The NPM is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results...