npj Precision Oncology is an international, peer-reviewed journal committed to publishing cutting-edge scientific research in all aspects of precision oncology from basic science to translational applications to clinical medicine. The journal defines precision oncology as cancer diagnosis, prognosis, preventio...
Tumor drug resistance emerges from the interaction of two critical factors: tumor cellular heterogeneity and the immunosuppressive nature of the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) constitute essential components of the TME.
2022npj Precision Oncology doi:10.1038/s41698-022-00254-ypmid:35228642 Patients with advanced anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer who are prescribed ALK-tyrosine kinase inhibitors (ALK-TKIs) rarely have complete responses, with residual tumors relapsing as heterogeneous...
In oncology clinical trials, many patients spend their final months at a central clinical trial facility far from home for “mandatory” protocol visits/diagnostic testing. Studies suggest that the travel strain may be greatest among patients living in l
40. LncRNAs are highly suited as oncology targets due to their superior tissue- and cancer-specific expression compared to protein-coding genes41,42,43. They have the potential to serve as clinically relevant biomarkers to improve diagnosis, prediction of recurrence, therapeutic targeting, treatment ...
CC-115, a dual inhibitor of DNA-PKcs and mTOR, sensitized lung cancer cell lines to etoposide, as well as suppressing NSCLC xenograft growth in vivo120,121. The first-in-human trial, completed in 2021, examined CC-115 in patients with advanced solid tumors (NCT01353625). CC-115 was well...
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AI in precision oncology Sections Figures References Abstract Introduction Results Discussion Methods Data availability Change history References Acknowledgements Author information Ethics declarations Additional information Supplementary information Rights and permissions About this article This article is cited by ...
npj Precision Oncology8, Article number:253(2024)Cite this article 1349Accesses 9Altmetric Metrics Abstract The role of collagen and its receptor, discoidin domain receptor 1 (DDR1) in immune response of colorectal cancer (CRC) remains unclear. We identified DDR1 as a promising target of immunot...
npj Precision Oncology Fuhao Wang, Shengqin Yue, Qingyu Huang, Tianyu Lei, Xiaohui Li, Cong Wang, Jinbo Yue & Chao Liu 1687 Accesses Explore all metrics Abstract Tissue-resident memory T cells (TRMs) play a critical role in cancer immunity by offering quick and effective immune ...