When insulin lispro and insulin aspart were compared in a single-blind, randomized, crossover study in 14 patients with type 1 diabetes, insulin lispro had a faster onset of action but a shorter duration (11). However, in another study the pharmacokinetic and the pharmacodynamic profiles of ins...
insulin‐naïvetype2diabetesBasal insulin peglispro (BIL) has a longer duration of action than conventional insulin analogues and a hepato‐preferential mechanism of action. This study assessed whether BIL was non‐inferior to isophane insulin (NPH) in reducing HbA1c in insulin‐naïve patients...
OBJECTIVE -- Insulin detemir is a soluble basal insulin analog with a unique mechanism of protracted action designed to reduce the variability associated with conventional basal insulins. This trial compared the glycemic control, risk of hypoglycemia, and effect on body weight of insulin detemir and...
The present invention is not limited to a particular mechanism of action. Indeed, an understanding of the mechanism is not necessary to practice the present invention. Nonetheless, in some embodiments, it is likely that both nephroretinin and nephrocystin, interact within a novel shared pathogenic...