Because most of the adhesion molecules are upregulated in inflammatory bowel diseases, therapeutic compounds have been designed directly against trafficking of lymphocytes into the intestinal mucosa, as a novel class of drugs in the treatment of IBD. In biological therapies against adhesion molecules, ...
A novel class of thioflavone and flavonoid derivatives has been prepared and their antiviral activities against enterovirus 71 (EV71) and the coxsackievirus B3 (CVB3) and B6 (CVB6) were evaluated. The thioflavone derivatives 7a, 7c, 7d, 7e, 7f and 7g, represent a new class of lead compoun...
(50)=2.91-3.77μM)together with low levels of activity against CVB3.Compound 7d exhibited stronger inhibitory activity against CVB3(IC_(50)=6.44μM)thaln CVB6(IC_(50)>8.29μM).The thioflavone derivatives 7a,7c,7d,7e,7f and 7g,represent a new class of lead compounds for the development...
Class III pistil-specific extensin-like proteins from tobacco have characteristics of arabinogalactan proteins. Plant Physiol. 2001;125:2180–8. Article CAS PubMed PubMed Central Google Scholar Eberle CA, Anderson NO, Clasen BM, Hegeman AD, Smith AG. PELPIII: the class III pistil-specific ...
A novel class of thioflavone and flavonoid derivatives has been prepared and their antiviral activities against enterovirus 71 (EV71) and the coxsackievirus B3 (CVB3) and B6 (CVB6) were evaluated. The thioflavone derivatives 7a, 7c, 7d, 7e, 7f and 7g, represent a new class of lead ...
7E). These data collectively support that DYRK2 plays a role in cell-cycle progression through CDC25A regulation. These results, together with those in response to genotoxic agents, demonstrate that an inverse correlation exists between DYRK2 and CDC25A at the protein level in response to ...
In particular, in the disease, the present invention relates to a use as targets experimental treatments specific role, and histone deacetylase 2, or diagnostic and especially histone deacetylase class.シュバイヒホッファー,ファビアンレサンク,アヌリス...
To develop a new class of MPO inhibitors with minimal toxicity, we synthesized a series of tripeptides that contained both Tyr and Cys. Here, we used Tyr, a natural substrate of MPO, to react with MPO oxidation intermediates. As anticipated, the reaction of Tyr with activated MPO resulted ...
and7e(X = CH3, OCH3, and Cl) respectively, the activity was lower than that of the standard. Concerning A549, the activity of all compounds of the series except compound7e(X = Cl) was better than the positive control and the best of them was compound7f(X = NO2). But...
El-Bayoumy K (1997) Organoselenium compounds: a novel class of cancer chemopreventive agents. Drugs Future 22:539–545 CAS Google Scholar Foroumadi A, Firoozpour L, Emami S, Mansouri S, Ebrahimabadi AH, Asadipour A, Amini M, Saeid-Adeli N, Shafiee A (2007) Synthesis and antibacterial ...