2022年3月24日,华中科技大学附属同济医院肿瘤科褚倩教授为通讯作者,在顶尖期刊《Signal Transduction and Targeted Therapy》(IF值为38.104分)上发表题为“Notch signaling pathway: architecture, disease, and therapeutics”的综述性文章,详细阐述了Notch 信号的研究历史及在生理、病理状态下的调控机制。下面笔者将综述全...
近年来,研究人员对Notch信号通路进行了广泛的研究,以探讨其在各种细胞环境中作为致癌基因或肿瘤抑制因子的作用。Notch信号通路在人类恶性肿瘤中的作用最初是在T细胞急性淋巴细胞白血病(T-ALL)中阐明的,随后的癌症基因组测序揭示了多种人类癌症中广泛存在...
no 15_suppl.3. Naoko Takebe, et al. Targeting notch signaling pathway in cancer: clinical develo...
[8]Zhang H,Xing J,etc.Lysine-specific demethylase 1 induced epithelial-mesenchymal transition and promoted renal fibrosis through Jagged-1/Notch signaling pathway.Hum Exp Toxicol.PMID:34396798.
[1]Zhou B H, Lin W L, Long Y L, et al. Notch signaling pathway: architecture, disease, and therapeutics[J]. Signal Transduct Target Ther, 2022, 7(1): 95. [2]王雪淞, 周林, 李林材, 等. Notch信号通路调控间充质干细胞的增殖与分...
Notch信号通路在肝纤维化发生过程中的作用 Notch信号通路与肝星状细胞(HSC)活化 HSC位于Disse间隙内,正常HSC的胞质内有富含类维生素A的脂滴(肝内维生素A的含量高达体内含量的80%,在贮存和代谢维生素A中发挥重要作用),可调节血管和肝窦血流,并具有产生胶原酶的能力。当肝受损时HSC被激活,转化为肌成纤...
In this review, the role ofNOTCH signaling pathway in cardiovascular diseases will be ntroduced including congenital heartdisease, heart failure and cardiomyopathies and arrhythmia, in order to provide new ideas for theclinical treatment of cardiovascular diseases.【Key words】 NOTCH signaling pathway...
文章来源:Li KX, Lu M, Cui MX, Wang XM, Zheng Y (2023) Astrocyte-neuron communication mediated by the Notch signaling pathway: focusing on glutamate transport and synaptic plasticity. Neural Regen Res 18(10):2285-2290.
[21]Chen JY,Feng L,Zhang HL,et al. Differential regulation of bonemarrow-derived endothelial progenitor cells and endothelial outgrowthcells by the Notch signaling pathway[J / OA]. PLoS One,2012,7( 10) : e43643. [22]Morell CM,Fiorotto R,Fabris L,et al. Notch signalling beyondliverdevelop...