Cell-Free Fetal DNA Is Not Present in Plasma of Nonpregnant Mothers [4] (multiple letters)Robbert J P RijndersGodelieve C M L ChristiaensAicha Ait SoussanC. Ellen Van Der SchootPietro InvernizziGiuseppe SimoniMauro Podda
While sex chromosomes carry sex-determining genes, they also often differ from autosomes in size and composition, consisting mainly of silenced heterochromatic repetitive DNA. Even though Y chromosomes show structural heteromorphism, the functional significance of such differences remains elusive. Correlative...
Based on findings in animals, allopurinol may cause fetal harm when administered to a pregnant woman. Adverse developmental outcomes have been described in exposed animals (see Data). Allopurinol and its metabolite oxypurinol have been shown to cross the placenta following administration of maternal a...
1. Maternal serum cell-free fetal DNA levels are increased in cases of trisomy 13 but not trisomy 18. [J] . Wataganara T, LeShane ES, Farina A, Human Genetics . 2003,第2期 机译:13号三体症患者的孕妇血清中无细胞胎儿DNA水平升高,而18号三体症患者则没有。 2. Cell-Free DNA Analysis ...
unless it is considered lifesaving for the mother. Fetal testing may be appropriate, based on the week of pregnancy. Patients and physicians should be aware, however, that oligohydramnios may not appear until after the fetus has sustained irreversible injury. Closely observe infants with histories...
While increasing evidence points to a key role of monocytes in amphibian host defenses, monocytes are also thought to be important in the dissemination and persistent infection caused by ranavirus. However, little is known about the fate of infected macr
Discovery of a spermatocele requires no therapy unless it islarge enough to annoy the patient, in which case it may be excised.Excision should be approached with caution to avoid compromisingthe passage of spermatozoa through the epididymis and vas deferens. Hernia. This mass is a sac-like ...
1 in MCs: some could not document expression of Munc18-1 in RBL-2H3 cells (23), others found expression and a functional role of Munc18-1 in degranulation of RBL-2H3 cells (24, 25), and others observed that the absence of Munc18-1 had no effects in fetal liver-derived MCs (26)...
The present knowledge on the safety profile and efficiency of lubeluzole seems to be promising enough to warrant further studies in immature animals. Recently, we were able to show that lubeluzole does not affect fetal circulatory centralization during acute asphyxia. This mechanism is of major ...
However, an important drawback of this method is that the sensitivity is not high enough when samples with a relatively low DNA concentration are used, because of the large amplified fragment (640 bp). To be able to perform large-scale sensitive screening for the common LCHAD mutation in ...