Figure 26.05.Nonsense Mutation A mutation in the DNA has produced a new stop codon that causes premature termination of the protein. The shortened protein remains unfolded and is usually detected by the cell and degraded. View chapterExplore book ...
A nonsense mutation results in the insertion of a premature stop codon into the DNA sequence. This results in translation terminating early and a truncated protein. Likely, this protein will not fold correctly and will not have full functionality. What happens in a nonsense mutation? A nonsense ...
Nonsense Mutationdoi:10.1007/978-3-642-16483-5_4124A mutation that occurs within a codon and changes it to a stop codon.Springer Berlin Heidelberg
Definition Nonsense mutation describes single‐base substitutions that change a sense codon coding for an amino acid into a termination codon, for instance UGG (tryptophan) to UGA (stop). Nonsense mutations are deleterious, as at such mutated positions the synthesis of the protein is terminated prem...
Nonsense Mutation 来自 Springer 喜欢 0 阅读量: 40 作者: JW Gooch 摘要: A mutation that creates an abnormal stop codon and thus causes translation to terminate prematurely; the resulting truncated protein is usually nonfunctional. DOI: 10.1007/978-1-4419-6247-8_14339 年份: 2011 ...
Summary. Hepatitis B virus (HBV) strains carrying the precore stop-codon mutation (A1896) have been considered among the predisposing factors for reactiva... A Alexopoulou,M Theodorou,SP Dourakis,... - 《Journal of Viral Hepatitis》 被引量: 88发表: 2010年 TET2 Mutations in Secondary Acute...
A nonsense mutation is a mutation that introduces a stop codon into the genetic code and prevents the protein from being made completely. How do you identify a silent mutation? You can identify a silent mutation by seeing if the mutation has any effect on the protein's structure ...
to test the sup-tRNA efficacy in another pathogenic mutation context, we considered the S466X mutation inCFTR, which occurs naturally with different stop codon identities (https://cftr2.org/). Since this mutation is implicated in cystic fibrosis, we considered the human bronchial epithelial CFBE...
Definition (Of or relating to) A mutation resulting in a nonsense or stop codon that does not code for an amino acid and is not transcribed (as distinguished from sense). Supplement Compare: missense Related term: nonsense mutation Last updated on June 23rd, 2021You will also like......
Define Nonsense mutation. Nonsense mutation synonyms, Nonsense mutation pronunciation, Nonsense mutation translation, English dictionary definition of Nonsense mutation. n. 1. The act or process of being altered or changed. 2. An alteration or change, as