All three translation termination codons, or nonsense codons, contain a uridine residue at the first position of the codon1"3. Here, we demonstrate that pseudouridylation (conversion of uridine into pseu-douridine (Ψ), ref. 4) of nonsense codons suppresses translation termination both in vitro...
5.Insolent talk or behavior; impudence:wouldn't take any nonsense from the children. adj. GeneticsOf or relating to a mutation in a structural gene that changes a nucleotide triplet into a stop codon, thus prematurely terminating the polypeptide chain during protein synthesis. ...
A CHANGE FROM NONSENSE TO SENSE IN THE GENETIC CODE Recent findings on the genetic code are reviewed, including selenocysteine usage, deviations in the assignments of sense and nonsense codons, RNA editing, natural ribosomal frameshifts and non-orthodox codon-anticodon pairings. A multi-s... BSP...
All three translation termination codons, or nonsense codons, contain a uridine residue at the first position of the codon. Here, we demonstrate that pseud... Karijolich,John,Yi-Tao,... - 《Nature》 被引量: 141发表: 2011年 A CHANGE FROM NONSENSE TO SENSE IN GENETIC CODE All three trans...
Selenium is an element which resembles sulfur in its physical and chemical properties. In minerals, selenium occurs mainly in the form of selenides which are associated with the isomorphic sulfides in a ratio ranging between 1:103 and 1:104. The chemical
Ten percent of inherited diseases are caused by premature termination codon (PTC) mutations that lead to degradation of the mRNA template and to the production of a non-functional, truncated polypeptide. In addition, many acquired mutations in cancer introduce similar PTCs. In 1999, proof-of-conce...
For adiscussion of these costly activities and their impact on societ... TJ Muris - 《Minnesota Law Review》 被引量: 192发表: 1981年 \\{RNA\\} pseudouridylation: new insights into an old modification {RNPs\\} and that such introduction can mediate nonsense-to-sense codon conversion, thus...
Identification of a selenocysteyl-tRNA(Ser) in mammalian cells that recognizes the nonsense codon, UGA. INTRODUCTION Selenocysteine (Sec), the 21st amino acid in the genetic code, is incorporated into a subset of proteins termed selenoproteins in response to ... BJ Lee,PJ Worland,JN Davis,....
Sensefromnonsense:therapiesforprematurestopcodondiseasesLaureBidou13Vale´rieAllamand34Jean-PierreRousset1andOlivierNamy11Universite´Paris-SudOrsayFranceInstitutdeGe´ne´tiqueetMicrobiologieCentreNationaldelaRechercheScientifiqueCNRSUMR861Orsay