Combining Sense and Nonsense Codon Reassignment for Site-Selective Protein Modification with Unnatural Amino Acids. ACS synthetic biology, doi:10.1021/acssynbio.6b00245 (2016).Cui Z, Mureev S, Polinkovsky ME, Tnimov Z, Guo Z, Durek T, et al. Combining sense and ...
All three translation termination codons, or nonsense codons, contain a uridine residue at the first position of the codon1"3. Here, we demonstrate that pseudouridylation (conversion of uridine into pseu-douridine (Ψ), ref. 4) of nonsense codons suppresses translation termination both in vitro...
All three translation termination codons, or nonsense codons, contain a uridine residue at the first position of the codon1, 2, 3. Here, we demonstrate that pseudouridylation (conversion of uridine into pseudouridine (Ψ), ref. 4) of nonsense codons suppresses translation termination both in vi...
originalsequenceandcouldleadto seriousmisinterpretation.Forexample, anATGtripletwouldappeartobea startcodon,butisinfactjusta GTAsequence. Thisisnotmerelyahypothetical problem.In1991,wediscoveredthree suchinstancesbyscreeningdatabases withthereversedM13mp18sequence ...
1. Interaction of nonsense suppressor tRNAs and codon nonsense mutations or termination codons [J] . Zixian Lu . 生物化学进展(英文) . 2012,第3期 2. Problems in Water Environmental Control—Sense and Nonsense in Measurement of Water Protection [J] . Stig Morling . 水资源与保护(英文) . 20...
nonsense (nŏn′sĕns′, -səns) n. adj. GeneticsOf or relating to a mutation in a structural gene that changes a nucleotide triplet into a stop codon, thus prematurely terminating the polypeptide chain during protein synthesis. The American Heritage® Medical Dictionary Copyright © 2007...
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An initiation codon missense muta... Acute intermittent porphyria (AIP), an autosomal dominant inborn error, results from the half-normal activity of the heme biosynthetic enzyme, hydroxymethy... CH Chen,KH Astrin,G Lee,... - Macmillan, 被引量: 134发表: 1994年 Sense and nonsense of ...
The MURFI linker for multiple reading frame insertion of a sense or nonsense codon into DNA 喜欢 0 阅读量: 1 作者:P Daniel,HO Halvorson DOI: 10.1093/nar/14.5.2139 被引量: 21 年份: 1986 收藏 引用 批量引用 报错 分享 全部来源 求助全文 dx.doi.org 引证文献...
This approach is attractive due to the large number of redundant sense codons and the lack of competition from the release factors that decrease the efficiency of the nonsense codon reassignment. Yet, the main obstacle for the efficient sense codon reassignment is the competition of native amino...