We reported that CERENKOV has state-of-the-art performance (by two traditional measures and a novel GWAS-oriented measure, AVGRANK) in a comparison to nine other tools for identifying functional noncoding SNPs, using a comprehensive reference SNP set (OSU17, 15,331 SNPs). Given that SNPs ...
The HGMD regulatory mutation model was trained with L1 regularization parameter 20 and L2 regularization parameter 2,000 for ten iterations. eQTL and GWAS SNP models were trained with L1 regularization parameter 0 and L2 regularization parameter 10 for 100 iterations. 可以看到这两个数据是分开train的,...
3e, PCAWG RPKM), 2.15-fold enriched for germline cancer-associated small nucleotide polymorphism (SNP) in their gene body (4.7% vs 2.5%) (Fig. 3e, SNPs per MB), and enriched in orthologues of driver lncRNAs carrying common insertion sites (CIS), discovered by transposon insertional ...
et al. SNP HiTLink: a high-throughput linkage analysis system employing dense SNP data. BMC Bioinformatics. 10, 121 (2009). Article CAS Google Scholar Gudbjartsson, D. F., Thorvaldsson, T., Kong, A., Gunnarsson, G. & Ingolfsdottir, A. Allegro version 2. Nat. Genet. 37, 1015–...
The results of this study indicate that SNP rs12803915 located in pre-mir-612, and SNP rs3746444 located in pre-mir-499, may represent novel markers of B-cell ALL susceptibility. 展开 关键词: Humans MicroRNAs RNA, Untranslated Child Genetic Association Studies Precursor Cell Lymphoblastic Leukemia...
RESULTS The assay revealed that reference SNP rs11776042 in piR-015551 was significantly associated with a decreased risk of CRC in an additive model ( P =.020). However, this protective effect was not significant after correction for multiple comparisons (test for the false discovery rate; P ...
Abbreviations HF: heart failure LV: left ventricle lncRNA: long noncoding RNA PBMC: peripheral blood mononuclear cells TAC: mouse transverse aortic constriction FFPE: formalin-fixed and paraffin-embedded SNP: single nucleotide polymorphism CAD: coronary artery diseases ...
left ventricle lncRNA: long noncoding RNA PBMC: peripheral blood mononuclear cells TAC: mouse transverse aortic constriction FFPE: formalin-fixed and paraffin-embedded SNP: single nucleotide polymorphism CAD: coronary artery diseases
摘要: Understanding SNP-dependent mechanism of regulation of functional lncRNA candidates in prostate cancer.关键词:CRISPR noncoding RNA prostate cancer risk SNP transcription DOI: 10.2217/epi-2016-0134 年份: 2017 收藏 引用 批量引用 报错 分享 ...
For example, an SNP in the first intron of ABO at the putative promoter of an antisense lncRNA was significantly associated with elevated fasting glucose levels (29). Mechanistically, how this noncoding region may be conferring disease risk or whether biological effects could be attributed to ...