Noncoding SequencesNoncoding sequences do not specify an amino acid sequence or a tRNA or rRNA. About 98 to 99% of the human genome is noncoding. They are generally clustered (e.g., in human chromosome 5q31) in...doi:10.1007/978-1-4020-6754-9_11488George P. Rédei...
which is much lower than the 100% conservation over 200 bp used to define mammalian ultraconserved elements4. Nonetheless, the set of 2,012 most highly conserved noncoding sequences (with, at most, 0.5 substitutions per site over at least 50 bp;Supplementary...
Comparative genomics approaches have identified numerous conserved cis-regulatory sequences near genes in plant genomes. Despite the identification of these conserved noncoding sequences (CNSs), our knowledge of their functional importance and selection
A conserved noncoding sequence can function as a spermatocyte-specific enhancer and a bidirectional promoter for a ubiquitously expressed gene and a testis- specific long noncoding RNA. J Mol Biol. 2014;426:3069-93.Kurihara M,Shiraishi A,Satake H,et al. A conserved noncodingsequence can ...
A statistical analysis of the occurrence of particular nucleotide runs in DNA sequences of different species has been carried out. There are considerable differences of run distributions in DNA sequences of procaryotes, invertebrates and vertebrates. There is an abundance of short runs (1鈥 2 ...
Mortlock DP, Pregizer S. 2012. Identifying functional annotation for noncoding genomic sequences. Curr Protoc Hum Genet. Chapter 1:Unit 1.10.Mortlock DP, Pregizer S (2012) Identifying functional annotation for noncoding genomic sequences . Curr Protoc Hum Genet Chapter 1: Unit1 10 PubMed: ...
A phylogeny for basal angiosperms based on noncoding, fast-evolving sequences of the chloroplast genome region trnT-trnF is presented. The recognition of simple direct repeats allowed a robust alignment. Mutational hot spots appear to be confined to certain sectors, as in two stem-loop regions ...
Therefore, accurate sequence-based prediction of chromatin features requires a flexible quantitative model capable of modeling such complex dependencies—and those predictions may then be used to estimate functional effects of noncoding variants.基于序列的,可以考虑到更多复杂的情况,这比单纯的依赖现有的motif...
The years following publication of the draft human genome sequence brought about a dramatic change in our understanding of the organization and expression of genetic information. Discoveries of new classes of RNA without protein coding potential and larg
sequence identical to their origin (Siomi, Sato, Pezic, & Aravin, 2011). Their biogenesis includes the interaction with the piwi-clad proteins whose slicer activity leads to the processing of thepiRNAantisense strand, which then itself acts as a lead against the original sequence.Downregulationof...