40.Non-Canonical NF-kB Signaling Pathway是细胞信号通路 教学讲解的第40集视频,该合集共计51集,视频收藏或关注UP主,及时了解更多相关视频内容。
Here we show a non-canonical pathway for Rb inactivation and its interplay with external signals. We find that the non-phosphorylated Rb protein in quiescent cells is intrinsically unstable, offering an alternative mechanism for initiating E2F activity. Nevertheless, this pathway in...
PTEN-null PDCs (P090) with exogenous mutants were treated with BKM120 to inhibit the PI3K/Akt signaling pathway. Surprisingly, invasive phenotypes were not significantly diminished by BKM120, compared toPTEN-null PDCs (Fig.4A). Edge mutants were still present at leading edges while retaining thei...
Non-canonical Pathway of MicroRNA Biogenesis Reference Work Title Encyclopedia of Systems Biology Pages p 1527 Copyright 2013 DOI 10.1007/978-1-4419-9863-7_101034 Print ISBN 978-1-4419-9862-0 Online ISBN 978-1-4419-9863-7 Publisher Springer New York Copyright Holder Springer Science+Business ...
Defects in non-canonical NF-κB signalling are associated with severe immune deficiencies, whereas dysregulated activation of this pathway contributes to the pathogenesis of various autoimmune and inflammatory diseases. Here we review the signalling mechanisms and the biological function of the non-...
The canonical pathway of osteoclast formation requires the presence of the receptor activator for NFkappaB ligand (RANKL) and macrophage colony stimulating factor (M-CSF). Non-canonical pathways of osteoclast formation have been described in which cytokines / growth factors can substitute for RANKL or...
Moreover, β-catenin-dependent Wnt pathway, referred to as canonical, has gained attention, while β-catenin-independent Wnt pathways, known as non-canonical, have remained conspicuously less explored. However, recent evidence about non-canonical Wnt pathways in stem cells begins to lay the ...
Tissue Transglutaminase Constitutively Activates HIF-1a Promoter and Nuclear Factor-κB via a Non-Canonical Pathway. Kumar S, Mehta K (2012) Tissue transglutaminase constitutively activates HIF-1α promoter and nuclear factor-κB via a non-canonical pathway . PLoS One ... Helbling,E Rachel,Aeschi...
NF-κB Inducing Kinase, a Central Signaling Component of the Non-Canonical Pathway of NF-κB, Contributes to Ovarian Cancer Progression NF-κB inducing kinase, a central signaling component of the non-canonical pathway of NF-κB, contributes to ovarian cancer progression. PLoS One 2014; ... U...
Our data reinforce previous reports suggesting no activation of canonical Wnt pathway in pituitary tumorigenesis. Moreover, we describe, for the first time, evidence that non-canonical Wnt pathways are also not mis-expressed in the pituitary tumors. 展开 ...