Upon stress, uORF expression is downregulated, and inhibition is reduced, resulting in increased protein expression in the coding region. In addition, stress upregulates eIF2A levels,140 and leads to the constitutive translation of uORF, which promotes translation of the coding-region proteins (3)...
Multiparametric prognostic scores in chronic heart failure with reduced ejection fraction: a long-term comparison Eur J Heart Fail, 20 (2018), pp. 700-710 CrossrefView in ScopusGoogle Scholar 17 F. Grothues, G.C. Smith, J.C. Moon, et al. Comparison of interstudy reproducibility of cardiov...
METase/lncRNA HULC/FoxM1 reduced cisplatin resistance in gastric cancer by suppressing autophagy. J Cancer Res Clin Oncol. 2019;145:2507–17. Article CAS PubMed Google Scholar Chen JF, Wu P, Xia R, Yang J, Huo XY, Gu DY, et al. STAT3-induced lncRNA HAGLROS overexpression contributes...
The ICD reduced arrhythmic mortality, but nonarrhythmic mortality increased in the patients who received an ICD. It was believed that low HRV in this patient population was an indicator of more advanced hemodynamic disease, and patients in the ICD group who received appropriate shocks ultimately ...
Most of the important biological mechanisms and functions of transmembrane proteins (TMPs) are realized through their interactions with non-transmembrane proteins(nonTMPs). The interactions between TMPs and nonTMPs in cells play vital roles in intracellu
domain (E280-A419) by the flow cytometry analysis. Finally, by the screening of single peptide in ELISA, we identified that the P99 peptide (393-TLLPAADLDDFSKQL-407) was the key epitope recognized by P301-H5. However, none of tested single peptides (P1 to P51, covering M1 to G215 ...
(SNPs) in the region of humanlncObwith lower plasma leptin levels and obesity. These results show that reduced leptin gene expression can lead to a hypoleptinemic, leptin-responsive form of obesity and provide a framework for elucidating the pathogenic mechanism in the subset of obese patients ...
performed 3D classification without alignment to pick out good particles with whole B6 density using Relion v.3.1.052coupled with cryoSPARC v.4.2.1. One rounds of 3D classification reduced the number of particles to 208,637 leading to an EM density map at an overall 3.46 Å resolution....
Tryptic Peptide MappingPass UV, pH, OD (concentration)Pass SDS-PAGEPass Isoelectric Focusing (IEF)Pass Analytic Biophysical Tests Circular Dichroism (CD)Pass Sedimentation velocity ultracentrifugationPass (SV-AUC) Differential Scanning Calorimetry (DSC)Pass ...
Inoculation of Alum and LLOT did not result in reduced infectious burden (FIGS. 5A-5B). Alum was less efficient than cholera toxin in eliciting LLO-specific total IgG and IgG1. In addition, the levels of IgG2a, IgG2b, and IgG3 were substantially lower when using alum in comparison to ...