transcription, and transcription control (“transcription (DNA-templated)”; “positive” or “negative regulation of transcription from RNA polymerase II promoter”; “covalent chromatin modification”; 264 genes). Table 2 Significantly enriched GO biological processes for protein coding genes overlapping ...
Frameshifting is a stochastic process, meaning that each translating ribosome has a certain probability of undergoing the shift, but that only a fraction of the ribosomes does so. Ribosomes that frameshift produce a translational fusion of the two overlapping ORFs, whereas those that do not ...
To further assess the performance disparities under the zero-shot setting, we leveraged identified PSMs from MaxQuant in each dataset as the benchmark. Then we compared the number of overlapping PSMs between the predicted PSMs generated by each de novo algorithm and the PSMs identified by MaxQuant...
, Ribosomes: molecular structure, role in biological functions and implications for genetic diseases, Nova Science Publishers (2013), pp. 67-86 View in ScopusGoogle Scholar [69] H. Seligmann An overlapping genetic code for frameshifted overlapping genes in Drosophila mitochondria: antisense anti...
Significance in the upper panel is determined by non-overlapping confidence intervals, exemplified by the marked data (orange stars), for the case of lorlR cells treated with alectinib on day 7 of relaxation. Full size image We find that there are patterns that change particularly quickly, such...
Supplementary Information Additional file 1: The protein–protein interaction information downloaded from HPRD. Additional file 2: The union of the 10 most significantly enriched pathways in the two disease modules and the genes overlapping between these modules. ...
Thus, lncRNAs can be transcribed either from a unique transcriptional locus, or from a locus overlapping a protein-coding gene in the sense or anti-sense direction [13]. Nascent lncRNAs are polyadenylated at the 3′ end and capped at the 5’ end, similar to protein-coding mRNAs [14]. ...
The traditional path of reverse genetic gene targeting for the entire lncRNA catalogue is not feasible [9–12]. Furthermore, doubts have been raised as to whether the observed phenotypes in knockout animals are the result of the loss of the lncRNA itself, or of an overlapping gene ...
We next performed paired analyses by classifying SCNAs overlapping significant loci from the unpaired analysis into three categories relative to their matched primary tumour: primary favoured, metastasis favoured or maintained (that is, found both in the primary tumour and its paired metastasis). We ...
two separate cassettes with 10 predicted mutated sites for either MCP only or QCP only, respectively, were designed and transfected together with both MCP-3xmCherry and QCP-3xBFP, into U2OS cells. (Right) Results for the orthogonality experiment: a cell presenting non-overlapping fluorescentfocifro...