Introduction:Anti-N-methyl D-aspartate (NMDA) receptor encephalitis is an autoimmune neurologic disorder that classically presents with psychiatric, neurologic, and autonomic symptoms, often with a viral prodrome. Case presentation:A 17-year-old female presented to the hospital with an 11-day history...
Anti-NMDA Receptor Encephalitis Presenting with Focal Non-Convulsive Status Epilepticus in a Child A previously healthy 9-year-old girl presented to an emergency department (ED) with headache, dizziness, blurry vision, and abnormal visual perceptions. Sh... E Goldberg,K Taub,S Kessler,... - 《...
Anti NMDAR encephalitis Anti NMDA receptor Encephalitis Autoimmune encephalitis 1. Introduction N-methyl-d-aspartate receptors (NMDAR) are ligand-gated cation channels for synaptic transmission and plasticity. NR1 subunits of receptor bind glycine whereas NR2 (A, B, C, or D) subunits bind with glu...
Both ICAM-1 and VCAM-1 have been specifically implicated in the control of lymphocyte entry into the brain following virally-induced encephalitis43 and in mouse and human studies of MS44. Other studies have found that ICAM-1 and VCAM-1 were upregulated in the ventricle region of the brains...
receptor have been utilized to transport large proteins such as nerve growth factor (NGF) across the blood–brain barrier (Granholm et al, 1994). More recently,Spencer and Verma (2007)reported the use of the lentivirus vector system to deliver the lysosomal enzyme glucocerebrosidase and a ...
process despite systemic immunotherapies (with a weak impact on the CNS compartments) has been postulated to be due to the infiltration of B cells and plasma cells into the CNS parenchyma as well as neighboring CSF compartments in patients with N-Methyl-D-Aspartate (NMDA) receptor encephalitis [...
process despite systemic immunotherapies (with a weak impact on the CNS compartments) has been postulated to be due to the infiltration of B cells and plasma cells into the CNS parenchyma as well as neighboring CSF compartments in patients with N-Methyl-D-Aspartate (NMDA) receptor encephalitis [...
Binding to the receptor-binding domain (RBD) of S1 was tested in an ELISA. To this end, a fusion protein (RBD-Fc) of the signal peptide of the NMDA receptor subunit GluN1, the RBD-SD1 part of SARS-CoV2-S1 (amino acids 319-591) and the constant region of rabbit IgG1 heavy chain...
Anti-NMDAR (Anti-N-Methyl-D-aspartic acid) encephalitis is a rare autoimmune condition mainly affecting young women. It is associated with an underlying tumor in about 50% of reported cases. Antibodies directed against the GIuN1 subunit of the NMDA receptor are responsible for the disease pathoge...
Anti-NMDA receptor encephalitis associated with an ovarian teratoma presenting as nonconvulsive status epilepticus with atypical ictal paroxysmal fast activityThomas, D FLivingston, MCurrey, KKrumholz, A