Anti-NMDAR (Anti-N-Methyl-D-aspartic acid) encephalitis is a rare autoimmune condition mainly affecting young women. It is associated with an underlying tumor in about 50% of reported cases. Antibodies directed against the GIuN1 subunit of the NMDA receptor are responsible for the disease pathoge...
Anti-NMDAR (Anti-N-Methyl-D-aspartic acid) encephalitis is a rare autoimmune condition mainly affecting young women. It is associated with an underlying tumor in about 50% of reported cases. Antibodies directed against the GIuN1 subunit of the NMDA receptor are responsible for the disease pathoge...
process despite systemic immunotherapies (with a weak impact on the CNS compartments) has been postulated to be due to the infiltration of B cells and plasma cells into the CNS parenchyma as well as neighboring CSF compartments in patients with N-Methyl-D-Aspartate (NMDA) receptor encephalitis [...
process despite systemic immunotherapies (with a weak impact on the CNS compartments) has been postulated to be due to the infiltration of B cells and plasma cells into the CNS parenchyma as well as neighboring CSF compartments in patients with N-Methyl-D-Aspartate (NMDA) receptor encephalitis [...
[23]. However, the effector mechanisms involved in the pathogenic effect of the autoantibodies within the CNS are not yet fully understood. In fact, autoantibodies in anti-NMDA-R and -AMPA-R, GABAB-R encephalitis are of the IgG1 and IgG3 type and are thus capable of activating complement ...
Schmitt, S. E.et al. Extreme delta brush: a unique EEG pattern in adults with anti-NMDA receptor encephalitis.Neurology79 Article et al. New-onset refractory status epilepticus: etiology, clinical features, and outcome. et al. Predictors of outcome in acute encephalitis. ...
Introduction:Anti-N-methyl D-aspartate (NMDA) receptor encephalitis is an autoimmune neurologic disorder that classically presents with psychiatric, neurologic, and autonomic symptoms, often with a viral prodrome. Case presentation:A 17-year-old female presented to the hospital with an 11-day history...
Kramina S, Kevere L, Bezborodovs N, Purvina S, Rozentals G, Strautmanis J, et al. Acute psychosis due to non-paraneoplastic anti-NMDA-receptor encephalitis in a teenage girl: case report. Psych J (2015) 4:226-30. doi:10.1002/ pchj.121...
Rhythmic delta activity represents a form of nonconvulsive in anti-NMDA receptor antibody encephalitis.drug identificationMedical Progress
Discussion Anti-NMDA receptor encephalitis is a recently described clinical entity that is typically seen in young females. It is considered paraneoplastic and has a close association with ovarian teratomas, however, approximately 40% of patients have no detectable tumor. Conclusions Autoimmune en ceph...